Compounds > lanosol
Page last updated: 2024-12-07

lanosol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,3-dibromo-4,5-dihydroxybenzyl alcohol: an antibacterial isolated from red sea algae [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID78659
CHEMBL ID253482
CHEBI ID80924
SCHEMBL ID935061
MeSH IDM0379391

Synonyms (16)

Synonym
2,3-dibromo-4,5-dihydroxybenzylalcohol
4950-06-5
1,2-benzenediol, 3,4-dibromo-5-(hydroxymethyl)-
3,4-dibromo-5-(hydroxymethyl)pyrocatechol
einecs 225-594-0
3,4-dibromo-5-(hydroxymethyl)1,2-benzenediol
inchi=1/c7h6br2o3/c8-5-3(2-10)1-4(11)7(12)6(5)9/h1,10-12h,2h
lanosol
chebi:80924 ,
CHEMBL253482
C17098
2,3-dibromo-4,5-dihydroxybenzyl alcohol
3,4-dibromo-5-(hydroxymethyl)benzene-1,2-diol
SCHEMBL935061
DTXSID10197814
Q27151424

Research Excerpts

Overview

Lanosol is a compound found in relatively high amounts in various marine species of Rhodophyta, including Odonthalia dentata.

ExcerptReferenceRelevance
"Lanosol is a compound found in relatively high amounts in various marine species of Rhodophyta, including Odonthalia dentata."( Effect of the dietary brominated phenol, lanasol, on chemical biotransformation enzymes in the gumboot chiton Cryptochiton stelleri (Middendorf, 1846).
Chimote, SS; Debusk, BC; Rimoldi, JM; Schenk, D, 2000)		1.03
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
catecholsAny compound containing an o-diphenol component.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID333152Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay2004Journal of natural products, Sep, Volume: 67, Issue:9
In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers.
AID313671Antifungal activity against Candida albicans ATCC 10231 after 48 to 72 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID313674Antifungal activity against Trichophyton mentagrophytes IFO 40996 after 48 to 72 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID313667Antibacterial activity against Micrococcus luteus IFC 12708 after 24 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID313668Antibacterial activity against Proteus vulgaris ATCC 3851 after 24 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID313669Antibacterial activity against Salmonella Typhimurium ATCC 14028 after 24 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID313673Antifungal activity against Trichophyton rubrum IFO 9185 after 48 to 72 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID313665Antibacterial activity against Staphylococcus aureus ATCC 6538p after 24 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID313670Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID333151Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay2004Journal of natural products, Sep, Volume: 67, Issue:9
In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers.
AID313666Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
AID379864Inhibition of yeast alpha-glucosidase by colorimetric method1999Journal of natural products, Jun, Volume: 62, Issue:6
Two new bromophenols from the red alga odonthalia corymbifera
AID313672Antifungal activity against Aspergillus fumigatus HIC6094 after 48 to 72 hrs2008Bioorganic & medicinal chemistry letters, Jan-01, Volume: 18, Issue:1
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's1 (12.50)24.3611
2020's2 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.14 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.14)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dinitrochlorobenzene
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.		210C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0210nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0410beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
protocatechualdehyde
protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure		2.0210dihydroxybenzaldehyde
bromates
Bromates: Negative ions or salts derived from bromic acid, HBrO3.		2.0110bromine oxoanion;
monovalent inorganic anion
3-bromo-4,5-dihydroxybenzaldehyde
3-bromo-4,5-dihydroxybenzaldehyde: a natural antioxidant from red algae (e.g., Rhodomela confervoides, Polysiphonia morrowii, and Polysiphonia urceolata)		2.0210
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0410antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
bis(2,3-dibromo-4,5-dihydroxybenzyl) ether
bis(2,3-dibromo-4,5-dihydroxybenzyl) ether: inhibits alpha-glucosidase; has antibacterial, antifungal, and cytotoxic activities; isolated from several red algae; structure in first source		210
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Coronavirus
[description not available]		02.2510
2019 Novel Coronavirus Disease
[description not available]		02.2510
Pneumonia, Viral
Inflammation of the lung parenchyma that is caused by a viral infection.		02.2510
Coronavirus Infections
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).		02.2510