Compounds > l-bornesitol
Page last updated: 2024-12-08

l-bornesitol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

L-bornesitol: Antineoplastic Agents, Phytogenic from Hancornia speciosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1D-3-O-methyl-myo-inositol : A member of the class of methyl myo-inositols that is cyclohexane-1,2,3,4,5-pentol substituted by a methoxy group at position 6 (the 1S,2R,3R,4S,5S,6R-isomer). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Hancorniagenus[no description available]ApocynaceaeThe dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH]

Cross-References

ID SourceID
PubMed CID440079
CHEBI ID28310
SCHEMBL ID7152886
SCHEMBL ID1129143
MeSH IDM0543018

Synonyms (14)

Synonym
CHEBI:28310
(1s,2r,3r,4s,5s,6r)-6-methoxycyclohexane-1,2,3,4,5-pentol
1d-3-o-methyl-myo-inositol
3-o-methyl-myo-inositol
(+)-bornesitol
l-bornesitol
C03660
SCHEMBL7152886
CCG-36390
SCHEMBL1129143
1l-1-o-methyl-myo-inositol
l-(+)-bornesito
Q27103627
(1s,2s,4r,5s)-6-methoxycyclohexane-1,2,3,4,5-pentol

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" We herein investigated the pharmacokinetic properties of bornesitol administered orally to Wistar rats, as well as bornesitol permeation in Caco-2 cells."( Determination of l-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa, in rat plasma by LC-MS/MS and its application on a pharmacokinetic study.
Braga, FC; Cortes, SF; de Castro, WV; de Pádua, RM; Feltrin, C; Gonçalves, JE; Moreira, LN; Simões, CMO, 2020)		0.56

Bioavailability

ExcerptReferenceRelevance
" Bornesitol reduced the blood pressure by a mechanism involving an increased production or bioavailability of NO, inhibition of ACE, and by an endothelium- and NO-dependent vasodilator effect."( The Cyclitol L-(+)-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant Hancornia speciosa.
Braga, FC; Câmara, DV; Cortes, SF; Lemos, VS; Moreira, LN; Pádua, RM; Silva, GC, 2019)		0.51
" The peak concentration and area under the concentration-time curve of bornesitol did not rise proportionally with the increasing doses, suggesting a non-linear pharmacokinetics in rats and the oral bioavailability ranged from 28."( Determination of l-(+)-bornesitol, the hypotensive constituent of Hancornia speciosa, in rat plasma by LC-MS/MS and its application on a pharmacokinetic study.
Braga, FC; Cortes, SF; de Castro, WV; de Pádua, RM; Feltrin, C; Gonçalves, JE; Moreira, LN; Simões, CMO, 2020)		0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.2110monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
quinic acid
(-)-quinic acid : The (-)-enantiomer of quinic acid.		2.7830
chlorogenic acid
caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.		2.1110cinnamate ester;
tannin		food component;
plant metabolite
rutin
Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.		2.4820disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
ConditionIndicatedRelationship StrengthStudiesTrials