Compounds > jci 3661
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jci 3661

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Description

JCI 3661: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID130317
CHEMBL ID447827
MeSH IDM0204700

Synonyms (11)

Synonym
jci 3661
CHEMBL447827
92832-17-2
3,3'-[(4-methoxyphenyl)methanediyl]bis[2-hydroxy-6-(propan-2-yl)cyclohepta-2,4,6-trien-1-one]
2-hydroxy-3-[(2-hydroxy-3-oxo-5-propan-2-ylcyclohepta-1,4,6-trien-1-yl)-(4-methoxyphenyl)methyl]-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
jci-3661
2,4,6-cycloheptatrien-1-one, 3,3'-((4-methoxyphenyl)methylene)bis(2-hydroxy-6-(1-methylethyl)-
alpha,alpha-bis(2-hydroxy-6-isopropyltropon-3-yl)-4-methoxytoluene
AKOS030538025
DTXSID00918939
3,3'-[(4-methoxyphenyl)methylene]bis[2-hydroxy-6-(propan-2-yl)cyclohepta-2,4,6-trien-1-one]
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID137087In vivo antitumor activity against leukemia P388 in mice after intraperitoneal administration at a dose of 2.5 mg/kg once a day for 1 and 5 days1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and antitumor activity of tropolone derivatives. 2.
AID72027Inhibit growth of FM3A cells by 50%1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
AID96183In vitro inhibition of KB cell growth.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 3.
AID153321Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 0.6 mg/kg1987Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
Synthesis and antitumor activity of tropolone derivatives. 4.
AID153034Antitumor activity in P388 inoculated mice following 10 mg/kg i.p. administration.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 3.
AID96391In vitro inhibitory activity against growth of KB cells1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and antitumor activity of tropolone derivatives. 2.
AID153057In vivo antitumor activity against leukemia P388 in mice at 5 mg/kg dosage administered intraperitoneally once a day for 1 and 5 days1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 5.
AID96217Antitumor activity was determined by the ability to inhibit KB cell growth1987Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives.
AID153036Antitumor activity against P388, was determined by injecting intraperitoneally in mice, at a dose of 10 mg/kg1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 3.
AID153043Antitumor activity in P388 inoculated mice following 5 mg/kg i.p. administration.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 3.
AID121933Antitumor activity against leukemia P388 cell line in mice was determined at 2.5 mg/kg intraperitoneal dose1987Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives.
AID153038Antitumor activity against P388, was determined by injecting intraperitoneally in mice, at a dose of 2.5 mg/kg1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 3.
AID154259Compound was tested in vivo for the antitumor activity against P388 in mice after intraperitoneal administration of 0.6 mg/kg dose; T/C= treated/control1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
AID96370Inhibit growth of KB cells by 50%1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
AID154402Compound was tested in vivo for the antitumor activity against P388 leukemia cells in mice after intraperitoneal administration of 5 mg/kg dose; T/C= treated/control1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
AID137083In vivo antitumor activity against leukemia P388 in mice after intraperitoneal administration at a dose of 0.6 mg/kg once a day for 1 and 5 days1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and antitumor activity of tropolone derivatives. 2.
AID137230In vivo antitumor activity was measured in mice (P388 leukemia) at dose 5 mg/kg after intraperitoneal administration1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Synthesis and antitumor activity of tropolone derivatives.
AID96018In vitro inhibitory activity against growth of KB cells derived from human epidermoid carcinoma of the mouth1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Synthesis and antitumor activity of tropolone derivatives.
AID154263Compound was tested in vivo for the antitumor activity against P388 in mice after intraperitoneal administration of 2.5 mg/kg dose; T/C= treated/control1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
AID153046In vivo antitumor activity against leukemia P388 in mice at 0.6 mg/kg dosage administered intraperitoneally once a day for 1 and 5 days1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 5.
AID121942Antitumor activity against leukemia P388 cell line in mice was determined at 5 mg/kg intraperitoneal dose1987Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives.
AID137226In vivo antitumor activity was measured in mice (P388 leukemia) at dose 2.5 mg/kg after intraperitoneal administration1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Synthesis and antitumor activity of tropolone derivatives.
AID137092In vivo antitumor activity against leukemia P388 in mice after intraperitoneal administration at a dose of 5 mg/kg once a day for 1 and 5 days1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and antitumor activity of tropolone derivatives. 2.
AID96368In vitro inhibition of KB cell growth1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 5.
AID137221In vivo antitumor activity was measured in mice (P388 leukemia) at dose 0.6 mg/kg after intraperitoneal administration1984Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
Synthesis and antitumor activity of tropolone derivatives.
AID153446Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 5 mg/kg1987Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
Synthesis and antitumor activity of tropolone derivatives. 4.
AID121930Antitumor activity against leukemia P388 cell line in mice was determined at 10 mg/kg intraperitoneal dose1987Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives.
AID72038Ability to induce dNTP pool imbalance at 41 uM dose was tested; significant imbalance in the intracellular dNTP pool in FM3A cells1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.
AID153325Compound was evaluated for activity against P388 leukemia, at an intraperitoneal dose of 2.5 mg/kg1987Journal of medicinal chemistry, Jan, Volume: 30, Issue:1
Synthesis and antitumor activity of tropolone derivatives. 4.
AID153049In vivo antitumor activity against leukemia P388 in mice at 2.5 mg/kg dosage administered intraperitoneally once a day for 1 and 5 days1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
Synthesis and antitumor activity of tropolone derivatives. 5.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (75.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oxyquinoline
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.		1.9810monohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
beta-thujaplicin
beta-thujaplicin: structure. beta-thujaplicin : A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.		2.3720cyclic ketone;
enol;
monoterpenoid		antibacterial agent;
antifungal agent;
antineoplastic agent;
antiplasmodial drug;
plant metabolite
hydroxyurea
[no description available]		1.9810one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
kojic acid
[no description available]		1.98104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		1.9610alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		1.9810antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
tropolone
Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).. tropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.		1.9810alpha-hydroxy ketone;
cyclic ketone;
enol		bacterial metabolite;
fungicide;
toxin
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		03.2260
Experimental Leukemia
[description not available]		01.9710
Carcinoma, Anaplastic
[description not available]		01.9610
Cancer of Mouth
[description not available]		01.9610
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		01.9610
Mouth Neoplasms
Tumors or cancer of the MOUTH.		01.9610
Experimental Mammary Neoplasms
[description not available]		01.9810