Page last updated: 2024-12-07

isoleucyl-prolyl-arginine-4-nitroanilide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

isoleucyl-prolyl-arginine-4-nitroanilide: chromogenic substrate for tissue plasminogen activator; RN given refers to D-Ile-L-Pro-L-Arg-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122006
SCHEMBL ID219560
MeSH IDM0122588

Synonyms (12)

Synonym
s 2288
77672-35-6
ile-pro-arg-p-na
chromogenic substrate s-2288
l-arginineamide, d-isoleucyl-l-prolyl-n-(4-nitrophenyl)-
isoleucyl-prolyl-arginine-4-nitroanilide
SCHEMBL219560
h-d-isoleucyl-l-prolyl-l-arginine-pnitroaniline dihydrochloride
(2s)-2-{[(2s)-1-[(2r,3r)-2-amino-3-methylpentanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamido-n-(4-nitrophenyl)pentanamide dihydrochloride
bdbm14715
n-[5-carbamimidamido-1-(4-nitroanilino)-1-oxopentan-2-yl]-1-isoleucylpyrrolidine-2-carboximidic acid
DTXSID60998878

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"Prophylaxis with 2-4 times weekly dosing of factor (F)VIII or FIX is established as an efficacious and safe treatment in haemophilia."( Generation and biochemical characterization of glycoPEGylated factor VIIa derivatives.
Bayer, RJ; Bjørn, SE; Holm, PK; Kalo, MS; Kinealy, K; Ostergaard, H; Stennicke, HR; Sørensen, BB; Zopf, D, 2008
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (26.09)18.7374
1990's12 (52.17)18.2507
2000's5 (21.74)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.28 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]