Page last updated: 2024-11-13

isoatriplicolide tiglate

Description

isoatriplicolide tiglate: from Paulownia coreana; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Paulowniagenus[no description available]Paulowniaceae[no description available]

Cross-References

ID SourceID
PubMed CID73350425
CHEMBL ID2380787
MeSH IDM0549006

Synonyms (5)

Synonym
bdbm50433419
chembl2380787 ,
isoatriplicolide tiglate
133559-39-4
AKOS040735988
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Transcriptional activator MybGallus gallus (chicken)IC50 (µMol)1.57000.62522.76989.5499AID746038
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Processvia Protein(s)Taxonomy
regulation of gene expressionTranscriptional activator MybGallus gallus (chicken)
mitotic cell cycleTranscriptional activator MybGallus gallus (chicken)
positive regulation of transcription by RNA polymerase IITranscriptional activator MybGallus gallus (chicken)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
protein bindingTranscriptional activator MybGallus gallus (chicken)
DNA-binding transcription factor activity, RNA polymerase II-specificTranscriptional activator MybGallus gallus (chicken)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTranscriptional activator MybGallus gallus (chicken)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
nucleoplasmTranscriptional activator MybGallus gallus (chicken)
nucleusTranscriptional activator MybGallus gallus (chicken)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID746038Inhibition of c-Myb-induced mim-1 gene expression in doxycyclin-treated chicken HD11 cells after 24 hrs by GFP assay2013European journal of medicinal chemistry, May, Volume: 63Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships.
AID746037Cytotoxicity against chicken HD11 cells assessed as cell viability after 24 hrs by MTS assay2013European journal of medicinal chemistry, May, Volume: 63Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships.
AID1811400Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 assessed as parasite growth inhibition2021European journal of medicinal chemistry, Dec-15, Volume: 226Synthesis and evaluation of tetrahydroisoquinoline derivatives against Trypanosoma brucei rhodesiense.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.20 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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