| Assay ID | Title | Year | Journal | Article |
|---|
| AID699249 | Activation of antithrombin L99F mutant in type 2 antithrombin deficiency patient plasma assessed as inhibition of S-2238 hydrolysis at 148 uM incubated for 5 mins in presence of mouse Py-4-1 cells (Rvb = 33.22 +/- 2.93%) | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699255 | Induction of conformational changes in purified human antithrombin assessed as induction of antithrombin polymer formation up to 14.8 uM at 37 or 42 degC incubated for 2 days in presence of urea by native PAGE | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699251 | Induction of conformational changes in purified human antithrombin assessed as induction of transition latent conformation up to 14.8 uM at 37 or 42 degC incubated for 2 days in absence of urea by native PAGE | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699246 | Activation of citrullinated human antithrombin-mediated inhibition of factor 10a assessed as chromogenic substrate hydrolysis at 14.8 uM in presence of rabbit skeletal muscle peptidyl arginase deaminase | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699257 | Activation of purified human antithrombin-mediated inhibition of thrombin assessed as second order association rate constant for chromogenic substrate hydrolysis by microplate reader based assay | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699252 | Activation of purified human antithrombin-high affinity heparin interaction assessed as antithrombin-mediated inhibition of thrombin by measuring as second order association rate constant for chromogenic substrate hydrolysis at 1 uM by microplate reader b | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699242 | Activation of purified human antithrombin-unfractionated heparin assessed as change in antithrombin intrinsic fluorescence at 37 uM by fluorescence spectrophotometry relative to untreated heparin control | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699256 | Induction of conformational changes in purified human antithrombin assessed as induction of transition latent conformation up to 14.8 uM at 37 or 42 degC incubated for 2 days in presence of urea by native PAGE | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699247 | Activation of antithrombin L99F mutant in type 2 antithrombin deficiency patient plasma assessed as inhibition of S-2238 hydrolysis at 148 uM incubated for 5 mins in presence of 1 uM unfractionated heparin (Rvb = 33.22 +/- 2.93%) | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699243 | Activation of purified human antithrombin-mediated inhibition of factor 10a assessed as second order association rate constant for chromogenic substrate hydrolysis by microplate reader based assay | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699244 | Activation of purified human antithrombin-low affinity heparin interaction assessed as antithrombin-mediated inhibition of thrombin by measuring as second order association rate constant for chromogenic substrate hydrolysis at 1 uM by microplate reader ba | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699241 | Activation of purified human antithrombin-unfractionated heparin interaction assessed as change in antithrombin intrinsic fluorescence by fluorescence spectrophotometry | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699254 | Induction of conformational changes in purified human antithrombin assessed as induction of antithrombin polymer formation up to 14.8 uM at 37 or 42 degC incubated for 2 days in absence of urea by native PAGE | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699248 | Activation of antithrombin in healthy human plasma assessed as inhibition of S-2238 hydrolysis at 148 uM incubated for 5 mins in presence of 1 uM unfractionated heparin | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID93054 | Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3,4,5-trisphosphate and D-myo-inositol 1,5, 6-trisphosphate: aspects of their structure-activity relationship to biologically active inositol phosphates. |
| AID699250 | Activation of antithrombin in healthy human plasma assessed as inhibition of S-2238 hydrolysis at 148 uM incubated for 5 mins in presence of mouse Py-4-1 cells | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699260 | Binding affinity to purified human antithrombin at 128 uM by isothermal titration calorimetry | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699253 | Activation of purified human antithrombin-high affinity heparin interaction assessed as antithrombin-mediated inhibition of factor 10a by measuring as second order association rate constant for chromogenic substrate hydrolysis at 1 uM by microplate reader | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| AID699245 | Activation of purified human antithrombin-low affinity heparin interaction assessed as antithrombin-mediated inhibition of factor 10a by measuring as second order association rate constant for chromogenic substrate hydrolysis at 1 uM by microplate reader | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |