Compounds > inositol 1,3-bisphosphate
Page last updated: 2024-12-07

inositol 1,3-bisphosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID128419
CHEBI ID18225
SCHEMBL ID9872231
SCHEMBL ID5003539
MeSH IDM0147430

Synonyms (28)

Synonym
myo-inositol 1,3-bis(dihydrogen phosphate)
CHEBI:18225
phosphoric acid mono-(2,3,4,6-tetrahydroxy-5-phosphonooxy-cyclohexyl) ester
C04062
d-myo-inositol 1,3-bisphosphate
myo-inositol 1,3-bisphosphate
103597-56-4
inositol 1,3-bisphosphate
DB02942
1JOC ,
SCHEMBL9872231
[(1s,2r,4s,5r)-2,3,4,6-tetrahydroxy-5-phosphonooxycyclohexyl] dihydrogen phosphate
inositol 1,3-diphosphate
myo-inositol, 1,3-bis(dihydrogen phosphate)
inositol(1,3)bisphosphate
1,5,-ip2
[(1r,2s,4r,5s)-2,3,4,6-tetrahydroxy-5-phosphonooxycyclohexyl] dihydrogen phosphate
gtpl5099
SCHEMBL5003539
d-myo-inositol-1,3-bis(dihydrogen phosphate)
PUVHMWJJTITUGO-FICORBCRSA-N
d-myo-inositol-1,3-diphosphate
(1r,2s,3s,4r,5s,6s)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)]
Q27102919
Q27070780
[(1r,2s,4r,5s)-2,3,4,6-tetrahydroxy-5-phosphonooxy-cyclohexyl]oxyphosphonic acid
DTXSID60869397
PD049692
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (3)

PathwayProteinsCompounds
Metabolism14961108
Inositol phosphate metabolism3235
Synthesis of IP2, IP, and Ins in the cytosol517

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Early Endosomal Autoantigen 1Homo sapiens (human)Kd24.000024.000024.000024.0000AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1811Experimentally measured binding affinity data derived from PDB2001Molecular cell, Nov, Volume: 8, Issue:5
Multivalent endosome targeting by homodimeric EEA1.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2001Molecular cell, Nov, Volume: 8, Issue:5
Multivalent endosome targeting by homodimeric EEA1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.67 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		2.0310acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
inositol 1,4,5-trisphosphate
Inositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.		2.3720myo-inositol trisphosphatemouse metabolite
inositol 3,4-bisphosphate
inositol 3,4-bisphosphate: RN given for (D)-isomer		1.9710myo-inositol bisphosphatehuman metabolite;
mouse metabolite
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		1.9710alkali metal atom
ConditionIndicatedRelationship StrengthStudiesTrials