Compounds > indoxyl phosphate
Page last updated: 2024-12-06

indoxyl phosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Indoxyl phosphate (IP) is a compound formed in the liver during the metabolism of tryptophan. It is a potential biomarker for kidney function, as its levels in the blood increase when the kidneys are not functioning properly. IP is synthesized from indoxyl sulfate, which is produced by the liver during the metabolism of tryptophan. IP can accumulate in the blood and tissues of patients with chronic kidney disease (CKD), and it has been linked to several complications of CKD, including cardiovascular disease, anemia, and bone disease. The accumulation of IP is thought to contribute to these complications by inducing oxidative stress and inflammation. IP is also being studied as a potential therapeutic target for CKD. The enzyme indoxyl sulfatase (IS) is responsible for the breakdown of IP. Studies are being conducted to develop drugs that can inhibit IS, thereby reducing the levels of IP in the blood and potentially improving the outcomes of patients with CKD.'

indoxyl phosphate: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID26292
SCHEMBL ID540158
MeSH IDM0105263

Synonyms (10)

Synonym
indoxylphosphate
1h-indol-3-yl dihydrogen phosphate
indoxyl phosphate
13822-19-0
1h-indol-3-ol, dihydrogen phosphate (ester)
SCHEMBL540158
DTXSID60160538
disodium,1h-indol-3-yl phosphate
FD10325
PD150848
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0310copper group element atom;
elemental silver		Escherichia coli metabolite
copper sulfate
Copper Sulfate: A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.. copper(II) sulfate : A metal sulfate compound having copper(2+) as the metal ion.		1.9610metal sulfateemetic;
fertilizer;
sensitiser
indoxyl
3-hydroxyindole: inhibits amyloid fibril formation; structure in first source		6.9610heteroaryl hydroxy compound;
hydroxyindoles
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		2.0210biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0210
Liver Dysfunction
[description not available]		01.9810
Liver Diseases
Pathological processes of the LIVER.		01.9810