imet 98-69 profile

Cross-References

ID Source	ID
PubMed CID	9577328
MeSH ID	M0067137

Synonyms (7)

Synonym
zimet 98/69
zimet 98-69
ethanone, 1-(3-(bis(2-hydroxyethyl)amino)phenyl)-, (4,5-diphenyl-2-oxazolyl)hydrazone
3-(di-(2-hydroxyethyl)amino)acetophenone (4,5-diphenyloxazol-2-yl)hydrazone
imet 98-69
34744-36-0
2-[3-[(z)-n-[(4,5-diphenyl-1,3-oxazol-2-yl)amino]-c-methylcarbonimidoyl]-n-(2-hydroxyethyl)anilino]ethanol

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
" The moderate bioavailability after oral administration of ZIMET 98/69 has to be considered as one reason for the high doses necessary for the antiviral action of the drug in vivo."	( Pharmacokinetics of 3-[bis(2-hydroxyethyl)amino]acetophenone-(4,5-diphenyloxazol-2-yl) hydrazone (ZIMET 98/69) after oral administration to mice. Amlacher, R; Ulbricht, H, 1985)	0.27
" Oral administration of 10 mg/kg results only a moderate bioavailability (25%), which further decreased after administration of higher doses."	( Pharmacokinetics of 3-[bis(2-hydroxyethyl)amino]acetophenone [4,5-diphenyloxazolyl-(2)]hydrazone (ZIMET 98/69) in rats. Amlacher, R; Hoffmann, H; Horn, U; Kramarczyk, K; Ulbricht, H, 1982)	0.26

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.66 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	3.06	5	0	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene

Condition	Relationship Strength	Studies
Arbovirus Infections Infections caused by arthropod-borne viruses, general or unspecified.	1.95	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.95	1
Enterovirus Infections Diseases caused by ENTEROVIRUS.	1.95	1
Infections, Orthomyxoviridae [description not available]	1.95	1
Vaccinia The cutaneous and occasional systemic reactions associated with vaccination using smallpox (variola) vaccine.	1.95	1
Viral Diseases [description not available]	1.95	1
Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE.	1.95	1
Virus Diseases A general term for diseases caused by viruses.	1.95	1

imet 98-69