Compounds > illudin m
Page last updated: 2024-12-08

illudin m

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID344199
CHEMBL ID501342
CHEBI ID5866
SCHEMBL ID232710
MeSH IDM0149440

Synonyms (40)

Synonym
spiro(cyclopropane-1,5'-(5h)inden)-7'(6'h)-one, 2',3'-dihydro-3'-beta,6'-alpha-dihydroxy-2',24',6'-tetramethyl-
brn 2286081
nsc 400978
ccris 3539
nsc 626370
nsc-626370
NCIMECH_000581
NCI60_003750
illudine m
dr-15977
NSC400978 ,
spiro[cyclopropane-1, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-,(3's,6'r)-
spiro[cyclopropane-1, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-,(3's-trans)-
nsc-400978
spiro[cyclopropane-1, 2',3'-dihydro-3'.beta.,6'.alpha.-dihydroxy- 2',2',4',6'-tetramethyl-
1146-04-9
C09687
illudin m ,
LMPR0103590001
(-)-illudin m
(-)-1alpha,7beta-dihydroxy-2,9-illudadien-8-one
CHEMBL501342
chebi:5866 ,
0aso6a4l61 ,
unii-0aso6a4l61
CCG-35652
SCHEMBL232710
illudin m [mi]
(3's-trans)-2',3'-dihydro-3,6-dihydroxy-2',2',4',6'-tetramethylspiro(cyclopropane-1,5'-(5h)inden)-7'(6'h)-one
spiro(cyclopropane-1,5'-(5h)inden)-7'(6'h)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3's,6'r)-
QVMDIQLUNODCTG-OCCSQVGLSA-N
CS-0085822
HY-122493
(1s,5r)-1,5-dihydroxy-2,2,5,7-tetramethyl-spiro[1h-indene-6,1'-cyclopropane]-4-one
Q27106919
(3's,6'r)-2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-spiro[cyclopropane-1,5'-[5h]inden]-7'(6'h)-one
(3's,6'r)-3',6'-dihydroxy-2',2',4',6'-tetramethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one
DTXSID801031276
AC-36762
AKOS040755316

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesquiterpenoidAny terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID387050Cytotoxicity against human PANC1 cells assessed as viable cells at 1 uM after 48 hrs by trypan blue exclusion assay relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387053Cytotoxicity against human HT-29 cells assessed as viable cells at 1 uM after 120 hrs by trypan blue exclusion assay relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387055Cytotoxicity against HFF cells assessed as viable cells at 1 uM after 120 hrs by trypan blue exclusion assay relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID1265759Chemical reactivity of the compound in aqueous HCl assessed as reaction rate2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Cytotoxic Illudane Sesquiterpenes from the Fungus Granulobasidium vellereum (Ellis and Cragin) Jülich.
AID387058Induction of apoptosis in human PANC1 cells assessed as sub-diploid DNA content at 1 uM after 120 hrs by FACS relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387059Induction of apoptosis in human HT-29 cells assessed as sub-diploid DNA content at 1 uM after 120 hrs by FACS relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387051Cytotoxicity against human HT-29 cells assessed as viable cells at 1 uM after 48 hrs by trypan blue exclusion assay relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387060Induction of apoptosis in HFF cells assessed as sub-diploid DNA content at 1 uM after 120 hrs by FACS relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387052Cytotoxicity against human PANC1 cells assessed as viable cells at 1 uM after 120 hrs by trypan blue exclusion assay relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387054Cytotoxicity against HFF cells assessed as viable cells at 1 uM after 48 hrs by trypan blue exclusion assay relative to control2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID387065Induction of apoptosis in human PANC1 cells assessed as sub-diploid DNA content at 0.1 uM by FACS2008Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
AID1265760Half life of the compound in aqueous HCl2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Cytotoxic Illudane Sesquiterpenes from the Fungus Granulobasidium vellereum (Ellis and Cragin) Jülich.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (11.76)18.7374
1990's1 (5.88)18.2507
2000's6 (35.29)29.6817
2010's4 (23.53)24.3611
2020's4 (23.53)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.63 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.94 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorambucil
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.		2.0410aromatic amine;
monocarboxylic acid;
nitrogen mustard;
organochlorine compound;
tertiary amino compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
endothall
endothall: minor descriptor (72-82); online & Index Medicus search DICARBOXYLIC ACIDS (72-82)		2.0410
n-heptane
Heptanes: Seven-carbon alkanes with the formula C7H16.. heptane : A straight-chain alkane with seven carbon atoms. It has been found in Jeffrey pine (Pinus jeffreyi).		2.4110alkane;
volatile organic compound		non-polar solvent;
plant metabolite
rhodium
Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.		210cobalt group element atom
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.0610iron group element atom;
platinum group metal atom
irofulven
irofulven: structure in first source		2.4320cyclohexenones
illudin s
[no description available]		3.2560sesquiterpenoid
tretinoin
Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.		2.4110retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
sesquiterpenes
[no description available]		4.04140
ptaquiloside
ptaquiloside: a norsesquiterpene from bracken fern (Pteridium aquilinum); not a pteridine; can be activated to alkylate DNA		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.0410
Cancer of Pancreas
[description not available]		02.0410
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0410
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.0410
Benign Neoplasms, Brain
[description not available]		02.4110
Glial Cell Tumors
[description not available]		02.4110
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.4110
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.4110
Malignant Melanoma
[description not available]		02.420
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.420
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0210
Abnormalities, Autosome
[description not available]		01.9710
Leukemia, Lymphocytic
[description not available]		01.9710
Acute Myelogenous Leukemia
[description not available]		01.9710
Leukemia, Lymphoid
Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.		01.9710
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		01.9710