Compounds > hydroxytriamterene sulfate ester
Page last updated: 2024-12-08

hydroxytriamterene sulfate ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

hydroxytriamterene sulfate ester: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID162951
CHEMBL ID3544822
MeSH IDM0086920

Synonyms (24)

Synonym
4-(2,4,7-triaminopteridin-6-yl)phenol hydrogen sulfate (ester)
hydroxytriamterene sulfate
sulfuric acid, 4-(2,4,7-triamino-6-pteridinyl)phenyl ester
phenol, 4-(2,4,7-triaminopteridin-6-yl)-, hydrogen sulfate (ester)
hydroxytriamterene sulfate ester
[4-(2,4,7-triaminopteridin-6-yl)phenyl] hydrogen sulfate
61867-18-3
hydroxytriamterene sulfuric acid ester
phenol, 4-(2,4-diamino-6-pteridinyl)-, hydrogen sulfate (ester)
p-hydroxytriamterene sulfate
7634cq9zjd ,
1476-48-8
unii-7634cq9zjd
FT-0670189
4-hydroxytriamterene sulfate
p-hydroxytriamterene sulfuric acid ester
phenol, p-(2,4,7-triamino-6-pteridinyl)-hydrogen sulfate (ester)
CHEMBL3544822
4-hydroxy triamterene sulfate,sodium salt
DTXSID10933158
4-(4-amino-2,7-diimino-1,2,3,7-tetrahydropteridin-6-yl)phenyl hydrogen sulfate
p-hydroxy triamterene sulfate
Q27266436
para-hydroxy triamterene sulfate

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Therefore, the aim of this study was to examine the dose linearity of TA and the pharmacokinetic and pharmacodynamic interaction of triamterene and hydrochlorothiazide."( Pharmacokinetics and pharmacodynamics of triamterene and hydrochlorothiazide and their combination in healthy volunteers.
Knauf, H; Möhrke, W; Mutschler, E, 1997)		0.3

Bioavailability

ExcerptReferenceRelevance
" Comparing these data with results after oral application of TA the bioavailability of TA was 52% and the extent of absorption 83%."( Pharmacokinetics of triamterene.
Gilfrich, HJ; Knauf, H; Möhrke, W; Mutschler, E; Völger, KD, 1983)		0.27

Dosage Studied

ExcerptRelevanceReference
" In the controls the average plasma concentration of triamterene during a dosage interval was 45 +/- 8 ng/ml and that of hydroxy-triamterene sulfate, an active metabolite of triamterene, was 967 +/- 177 ng/ml."( Kinetics and dynamics of triamterene at steady-state in patients with cirrhosis.
Dao, MT; Villeneuve, JP, 1988)		0.27
"In this study we compared the absorption and disposition of two commonly used combination formulations of hydrochlorothiazide and triamterene (Dyazide and Maxzide) in 48 patients with essential hypertension after dosing with each formulation to steady state."( Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function.
Benet, LZ; Blume, C; Clark, TS; Lin, E; Thornhill, MD; Upton, RA; Williams, RL, 1986)		0.27
" The bioavailability of different dosage forms was correlated with in vitro tests."( Pharmacokinetics of triamterene.
Gilfrich, HJ; Knauf, H; Möhrke, W; Mutschler, E; Völger, KD, 1983)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (61.54)18.7374
1990's3 (23.08)18.2507
2000's2 (15.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.37 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.15 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (7.14%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
furosemide
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.. furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.		2.6630chlorobenzoic acid;
furans;
sulfonamide		environmental contaminant;
loop diuretic;
xenobiotic
hydrochlorothiazide
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.. hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.		3.7721benzothiadiazine;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		1.9610catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
triamterene
Triamterene: A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.. triamterene : Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.		6.22131pteridinesdiuretic;
sodium channel blocker
rotenone
Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.		2.0310organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
benzofuran
benzofuran: RN & structure given in first source. 1-benzofuran : A benzofuran consisting of fused benzene and furan rings. It is the parent compound of the class of 1-benzofurans.		2.03101-benzofurans;
benzofuran
amiloride
Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). amiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.		2.910aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker
calcium oxalate
Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.. calcium oxalate : The calcium salt of oxalic acid, which in excess in the urine may lead to formation of oxalate calculi (kidney stones).		1.9610organic calcium salt
4-hydroxytriamterene
4-hydroxytriamterene: active metabolite of triamterene; RN given refers to cpd with OH in para position		2.3720
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Liver Dysfunction
[description not available]		01.9610
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.		01.9610
Liver Diseases
Pathological processes of the LIVER.		01.9610
Kidney Stones
[description not available]		02.3720
Kidney Calculi
Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.		02.3720
Cirrhosis, Liver
[description not available]		01.9710
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.		01.9710
Blood Pressure, High
[description not available]		01.9610
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		01.9610
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		01.9610