hydroxystreptomycin

Description

Hydroxystreptomycin is a semisynthetic aminoglycoside antibiotic derived from streptomycin. It is produced by chemical modification of streptomycin, specifically by introducing a hydroxyl group at the C-5 position of the streptidine moiety. Hydroxystreptomycin exhibits enhanced activity against certain bacterial strains, particularly Mycobacterium tuberculosis, compared to its parent compound, streptomycin. Its mechanism of action involves binding to the 16S rRNA of bacterial ribosomes, interfering with protein synthesis and ultimately leading to bacterial cell death. Hydroxystreptomycin has been clinically used for the treatment of tuberculosis, but its use has declined due to the emergence of resistance and the availability of newer, less toxic antibiotics. Research into hydroxystreptomycin has focused on understanding its mechanism of action, developing new strategies to overcome resistance, and exploring its potential applications in other areas, such as cancer therapy.'

hydroxystreptomycin: antibiotic from Streptomyces reticuli H 365 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5'-hydroxystreptomycin : A streptomycin bearing an additional hydroxy substituent at the 5'-position (on the furanose ring) [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]