Compounds > hydnocarpic acid
Page last updated: 2024-12-07

hydnocarpic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Hydnocarpic acid is a saturated fatty acid found in the seeds of the chaulmoogra tree (Hydnocarpus wightiana). It has been used traditionally in the treatment of leprosy. The molecule contains a cyclopentenyl ring, which is responsible for its biological activity. It has been shown to have anti-inflammatory and anti-bacterial properties. Hydnocarpic acid and its derivatives have been investigated for their potential in treating various diseases, including leprosy, tuberculosis, and cancer. Studies have explored its mechanisms of action, including its ability to inhibit bacterial growth and its interactions with specific enzymes. However, its use is limited due to its potential side effects, such as nausea, vomiting, and diarrhea. Despite the development of more effective treatments for leprosy, hydnocarpic acid remains an important subject of research for its potential therapeutic applications.'

hydnocarpic acid: cyclopentenyl fatty acid; component of chaulmoogra oil [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

hydnocarpic acid : A cyclopentenyl fatty acid consisting of undecanoic acid having a cyclopent-2-enyl group at the 11-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID110680
CHEBI ID61671
SCHEMBL ID580439
MeSH IDM0045665

Synonyms (30)

Synonym
hydnocarpic acid,(d)
d-hydnocarpic acid
NSC51168 ,
nsc-51168
nsc-313950
94300-40-0
NSC313950 ,
hydnocarpic acid
2-cyclopentene-1-undecanoic acid
11-(2-cyclopentenyl)-undecanoic acid
11-(cyclopent-2-enyl)hendecanoic acid
LMFA01140023
11-cyclopent-2-en-1-ylundecanoic acid
11-cyclopent-2-enyl-undecansaeure
hydnocarpsaeure
11-cyclopent-2-enyl-undecanoic acid
11-cp 11:0
CHEBI:61671
SCHEMBL580439
11-(2-cyclopenten-1-yl)undecanoic acid #
11-(2-cyclopenten-1-yl)undecanoic acid, (+)-
SRELFLQJDOTNLJ-UHFFFAOYSA-N
11-(2-cyclopentenyl)undecanoic acid
u88t2w388k ,
hydnocarpic acid, (+/-)-
dl-hydnocarpic acid
hydnocarpic acid dl-form [mi]
unii-u88t2w388k
Q2823268
(+/-)-hydnocarpic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
cyclopentenyl fatty acidA carbocyclic, unsaturated fatty acid containing a cyclopentene ring at any point in the carbon chain.
monounsaturated fatty acidAny fatty acid with one double or triple bond in the fatty acid chain and singly bonded carbon atoms in the rest of the chain. MUFAs have positive effects on the cardiovascular system, and in diabetes treatment.
long-chain fatty acidA fatty acid with a chain length ranging from C13 to C22.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.30

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.30 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.30)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
clofazimine
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619). clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.		1.9710monochlorobenzenes;
phenazines		dye;
leprostatic drug;
non-steroidal anti-inflammatory drug
dapsone
[no description available]		2.3820substituted aniline;
sulfone		anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.3620cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
asiaticoside
[no description available]		1.9710
chaulmoogric acid
chaulmoogric acid: component of CHAULMOOGRA OIL; RN given refers to parent cpd; structure. (R)-chaulmoogric acid : The (R)-enantiomer of chaulmoogric acid.. chaulmoogric acid : A monounsaturated long-chain fatty acid composed of tridecanoic acid having a 2-cyclopentenyl substituent at the 13-position.		1.9810chaulmoogric acid
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		1.9710cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Hansen Disease
[description not available]		02.3720
Leprosy
A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.		02.3720
Leprosy, Cutaneous
[description not available]		01.9710