Compounds > humantenine
Page last updated: 2024-11-13

humantenine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

humantenine: isolated from root of Hu-Man-Teng (Gelsemium elegans Benth.); structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44593672
CHEMBL ID523399
MeSH IDM0131984

Synonyms (9)

Synonym
humantenine
CHEMBL523399
19(z)-akuammidine
(19z)-rhazine
(1r,2s,4s,7z,8r,9s)-7-ethylidene-1'-methoxy-5-methylspiro[11-oxa-5-azatricyclo[6.3.1.04,9]dodecane-2,3'-indole]-2'-one
CS-0024484
HY-N4031
DTXSID601318183
AKOS040760452
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID376637Cytotoxicity against human A431 cells after 48 hrs by trypan blue test2006Journal of natural products, Apr, Volume: 69, Issue:4
Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells.
AID337723Cytotoxicity against human KB cells
AID1762379Analgesic activity in Kunming mouse assessed as inhibition of acetic acid-induced writhing at 5 mg/kg, ip pretreated with compound for 30 mins followed by acetic acid challenge and measured after 30 mins
AID337722Cytotoxicity against mouse P388 cells
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's4 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
yohimbane
yohimbane: from Gelsemium elegans; structure in first source		7.1110indole alkaloid fundamental parent;
indole alkaloid;
yohimban alkaloid
koumine
koumine: structure in first source		7.1110indoles
humantenirine
humantenirine: isolated from root of Hu-Man-Teng (Gelsemium elegans Benth.); structure given in first source		6.9610
gelsemoxonine
gelsemoxonine: isolated from Gelsemium elegans Benth; structure in first source		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.4110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.4110