Compounds > hiv envelope protein gp41 (519-541)
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hiv envelope protein gp41 (519-541)

Description

HIV envelope protein gp41 (519-541): the amino terminal peptide of HIV envelope protein gp41; lyses human erythrocytes and CD4+ lymphocytes [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16132114
MeSH IDM0205599

Synonyms (7)

Synonym
hiv envelope protein gp41 (519-541)
128631-86-7
l-serinamide, l-alanyl-l-valylglycyl-l-isoleucylglycycl-l-alanyl-l-leucyl-l-phenylalanyl-l-leucylglycyl-l-phenylalanyl-l-leucylglycyl-l-alanyl-l-alanylglycyl-l-seryl-l-threonyl-l-methionylglycyl-l-alanyl-l-arginyl-
l-alanyl-l-valylglycyl-l-isoleucylglycyl-l-alanyl-l-leucyl-l-phenylalanyl-l-leucylglycyl-l-phenylalanyl-l-leucylglycyl-l-alanyl-l-alanylglycyl-seryl-l-threonyl-l-methionylglycyl-l-alanyl-l-arginyl-l-serinamide
fp-1, hiv
l-serinamide, l-alanyl-l-valylglycyl-l-isoleucylglycyl-l-alanyl-l-leucyl-l-phenylalanyl-l-leucylglycyl-l-phenylalanyl-l-leucylglycyl-l-alanyl-l-alanylglycyl-l-seryl-l-threonyl-l-methionylglycyl-l-alanyl-l-arginyl-
DTXSID90155952

Dosage Studied

ExcerptReference
" Dose-response curves indicated that their relative potency in inhibiting FP-I-induced hemolysis was approximately correlated with their previously reported anti-HIV activity."( Antivirals that target the amino-terminal domain of HIV type 1 glycoprotein 41.
Curtain, CC; Faull, K; Gordon, LM; Kirkpatrick, A; Leung, C; Mobley, PW; Waring, AJ, 1995)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (85.71)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
melitten
Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.		2.3820
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.6730
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.6730