hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine profile

Cross-References

ID Source	ID
PubMed CID	535289
CHEBI ID	24559
SCHEMBL ID	2681932
MeSH ID	M0495335

Synonyms (11)

Synonym
5755-27-1
1,3-dinitro-5-nitroso-1,3,5-triazinane
hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine
CHEBI:24559
s-triazine, hexahydro-1,3-dinitro-5-nitroso-
ccris 9501
SCHEMBL2681932
LOSVOOKTCVILPF-UHFFFAOYSA-N
1,3-dinitro-5-nitroso-1,3,5-triazinane #
1-nitroso-3,5-dinitro-hexahydro-1,3,5-triazine
Q27109845

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" LC20 and LC50 for TNX were slightly lower than for MNX; this indicates that TNX was more toxic than MNX."	( Toxicity of the explosive metabolites hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX) and hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) to the earthworm Eisenia fetida. Anderson, TA; Kendall, RJ; Zhang, B, 2006)	0.55

Bioavailability

Excerpt	Reference	Relevance
"The uptake kinetics of two major RDX (hexahydro-1,3,5-trinitro-1,3,5-triazacyclohexane) metabolites, hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), into passive sampling devices (PSDs), and the ability of PSDs to serve as surrogates for evaluating bioavailability of MNX and TNX were investigated in laboratory sand and two soil types."	( Evaluating the bioavailability of explosive metabolites, hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), in soils using passive sampling devices. Anderson, TA; Smith, PN; Zhang, B, 2006)	0.79

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

Class	Description
1,3,5-triazinanes
N-nitro compound	A compound having the nitro group (-NO2) attached to a nitrogen atom.
nitrosamine	N-Nitroso amines, compounds of the structure R2NNO. Compounds RNHNO are not ordinarily isolable, but they, too, are nitrosamines. The name is a contraction of N-nitrosoamine and, as such, does not require the N locant.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (44.44)	29.6817
2010's	5 (55.56)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.15 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.46 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
sym-trinitrobenzene Trinitrobenzenes: Benzene derivatives which are substituted with three nitro groups in any position.. 1,3,5-trinitrobenzene : A trinitrobenzene in which each of the nitro groups is meta- to the other two.	2.13	1	trinitrobenzene	explosive
4-nitroanisole 4-nitroanisole: dye intermediate; organic synthesis; structure. 4-nitroanisole : A member of the class of 4-nitroanisoles that is anisole in which one the hydrogen meta to the methoxy group is replaced by a nitro group.	2.13	1	4-nitroanisoles
cyclonite cyclonite: explosive & convulsant; structure. 1,3,5-trinitro-1,3,5-triazinane : An N-nitro compound that is 1,3,5-triazinane in which all three of the hydrogens attached to the nitrogens have been replaced by nitro groups. It is widely used in both industrial and military explosives.	3.57	8	1,3,5-triazinanes; N-nitro compound	explosive
octadecane octadecane: RN given refers to parent cpd. octadecane : A straight-chain alkane carrying 18 carbon atoms.	2.03	1	long-chain alkane	bacterial metabolite; plant metabolite
trinitrosotrimethylenetriamine [no description available]	2.74	3	1,3,5-triazinanes; nitrosamine

hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine