Hexachloronaphthalene (HxCN) is a highly chlorinated polycyclic aromatic hydrocarbon (PAH) that exists as a complex mixture of isomers. It was primarily produced and used as a dielectric fluid in electrical equipment, particularly transformers, due to its excellent insulating properties. HxCN has been found to be a persistent organic pollutant (POP), meaning it resists degradation in the environment and can accumulate in living organisms. Studies on HxCN have focused on its environmental fate, toxicity, and potential health effects, particularly its role in bioaccumulation and its potential for causing cancer. The synthesis of HxCN involves the chlorination of naphthalene, a process that can result in a wide range of isomers with varying degrees of chlorination. Concerns about the environmental and health risks associated with HxCN have led to its phased-out production and use in many countries, but it remains a concern due to its persistence in the environment and its potential for long-term exposure.'
| ID Source | ID |
|---|---|
| PubMed CID | 108177 |
| SCHEMBL ID | 1077252 |
| MeSH ID | M0140715 |
| Synonym |
|---|
| 1335-87-1 |
| naphthalene, 1,2,3,4,5,6-hexachloro |
| hexachloronaphthalene |
| 1,2,3,4,5,6-hexachloronaphthalene |
| 58877-88-6 |
| naphthalene, 1,2,3,4,5,6-hexachloro- |
| SCHEMBL1077252 |
| CTLMCQOGOWNFHA-UHFFFAOYSA-N |
| DTXSID00871838 |
Hexachloronaphthalene (HxCN) is one of the most toxic congeners of polychlorinated naphthalenes (PCNs) Anorectic effect, with concurrent significant increase in relative liver mass was the most spectacular symptom of the toxic effect.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Our study provided evidence that the anorectic effect, with concurrent significant increase in relative liver mass was the most spectacular symptom of the toxic effect of hexachloronaphthalene in the rats after its single (250mg/kg) and repeated (1 and 10mg/kg) administration." | ( Toxicity of hexachloronaphthalene (HxCN) and induction of CYP 1A in rats. Kilanowicz, A; Skrzypinska-Gawrysiak, M, 2010) | 0.93 |
| "Hexachloronaphthalene (HxCN) is one of the most toxic congeners of polychlorinated naphthalenes (PCNs)." | ( Developmental toxicity of hexachloronaphthalene in Wistar rats. A role of CYP1A1 expression. Bruchajzer, E; Czech, E; Czekaj, P; Darago, A; Kilanowicz, A; Plewka, D; Sapota, A; Sitarek, K; Skrzypinska-Gawrysiak, M; Wiaderkiewicz, A, 2015) | 2.16 |
| "Hexachloronaphthalenes (HxCNs) are the most toxic congeners of polychlorinated naphthalenes, a group of compounds lately included into the list of persistent organic pollutants (POPs)." | ( The effects of hexachloronaphthalene on selected parameters of heme biosynthesis and systemic toxicity in female wistar rats after 90-day oral exposure. Bruchajzer, E; Darago, A; Domeradzka-Gajda, K; Kilanowicz, A; Klimczak, M; Kuzajska, K; Stepnik, M, 2018) | 2.28 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.73) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||