Compounds > hexabromodiphenyl ether 154
Page last updated: 2024-11-12

hexabromodiphenyl ether 154

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

2,2',4,4',5,6'-hexabromodiphenyl ether: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15509898
CHEBI ID81535
SCHEMBL ID14938618
MeSH IDM0527762

Synonyms (22)

Synonym
bde 154
pbde 154
207122-15-4
2,2',4,4',5,6'-hexabromodiphenyl ether
C18138
bde-154
hexabromodiphenyl ether 154
benzene, 1,3,5-tribromo-2-(2,4,5-tribromophenoxy)-
pbed 154
ogy508qk5u ,
unii-ogy508qk5u
CHEBI:81535
DTXSID3052692
SCHEMBL14938618
VHNPZYZQKWIWOD-UHFFFAOYSA-N
1,3,5-tribromo-2-(2,4,5-tribromophenoxy)benzene
J-013539
Q27155451
1,2,4-tribromo-5-(2,4,6-tribromophenoxy)benzene
pbde no. 154
pbde 154 50 microg/ml in nonane
34i - wfd i

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Unlike other extensively reported congeners, BDE-154 was only toxic at the higher tested concentrations, whereas BDE-47 cytotoxicity was evident even at lower concentrations."( Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47).
Dorta, DJ; Duarte, FV; Oliveira, AM; Oliveira, DP; Palmeira, CM; Pereira, LC; Souza, AO; Tasso, MJ, 2016)		0.43
" The use of halogen-free flame retardants (HFFR) has increased as a safer alternative, but little information is available on their toxic potential for environmental health and for developing organisms."( A comparison of developmental toxicity of brominated and halogen-free flame retardant on zebrafish.
Abe, FR; de Oliveira, AÁS; Dorta, DJ; Marino, RV; Oliveira, DP; Rialto, TCR, 2021)		0.62
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
organobromine compoundA compound containing at least one carbon-bromine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (12.50)29.6817
2010's19 (79.17)24.3611
2020's2 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hexachlorocyclohexane
Lindane: An organochlorine insecticide made up of greater than 99% gamma-Hexachlorocyclohexane. It has been used as a pediculicide and scabicide, and shown to cause cancer.. beta-hexachlorocyclohexane : The beta-isomer of hexachlorocyclohexane.		2.110chlorocyclohexane
dichlorodiphenyl dichloroethylene
Dichlorodiphenyl Dichloroethylene: An organochlorine pesticide, it is the ethylene metabolite of DDT.		2.520chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt
1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane: structure in first source		2.110benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
thyroxine
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.		2.48202-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
decabromobiphenyl ether
decabromobiphenyl ether: a flame retardant. decabromodiphenyl ether : A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.		3.4870polybromodiphenyl etherneurotoxin
2,2',3',4,4',5-hexachlorobiphenyl
[no description available]		2.110polychlorobiphenyl
2,3,6,2',3',6'-hexachlorobiphenyl
[no description available]		2.1110hexachlorobiphenyl
bde 206
2,2',3,3',4,4',5,5',6-nonabromodiphenyl ether: structure in first source		2.1510
2,2',4,4'-tetrabromodiphenyl ether
[no description available]		4.17150aromatic ether;
organobromine compound
bde 207
2,2',3,3',4,4',5,6,6'-nonabromodiphenyl ether: structure in first source		2.5120
bde 197
2,2',3,3',4,4',6,6'-octabromodiphenyl ether: a component of DE-79, a technical octabromo diphenyl ether mixture		2.1510
tribromodiphenyl ether 28
4-bromophenyl 2,4-dibromophenyl ether : A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, and 4' positions have been replaced by bromines.		3.4970polybromodiphenyl ether
2,2',4,5'-tetrabromodiphenyl ether
[no description available]		2.5420aromatic ether;
organobromine compound
bde 183
2,2',3,4,4',5',6-heptabromodiphenyl ether: a polybrominated diphenyl ether compound		2.7930aromatic ether;
organobromine compound
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Sterility, Male
[description not available]		02.610
Infertility, Male
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.		02.610
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0710