Compounds > herpetrione
Page last updated: 2024-11-12

herpetrione

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

herpetrione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16037396
MeSH IDM0586503

Synonyms (3)

Synonym
3-hydroxy-2-[2-hydroxy-5-[3-(4-hydroxy-3-methoxy-phenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-3-methoxy-phenyl]-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one
herpetrione
hpe ,

Research Excerpts

Overview

Herpetrione (HPE) is a new compound extracted from Herpetospermum caudigerum. It is proved to be a novel and potent antiviral agent.

ExcerptReferenceRelevance
"Herpetrione (HPE), is a new compound extracted from Herpetospermum caudigerum, which is proved to be a novel and potent antiviral agent. "( Development and in vivo/in vitro evaluation of novel herpetrione nanosuspension.
Fu, SS; Guo, JJ; Han, J; Jin, SX; Jin, SY; Lv, JL; Yuan, HL; Yue, PF, 2013)		2.08

Bioavailability

ExcerptReferenceRelevance
" However, due to poor water solubility, oral bioavailability of the drug was relatively low."( Development and in vivo/in vitro evaluation of novel herpetrione nanosuspension.
Fu, SS; Guo, JJ; Han, J; Jin, SX; Jin, SY; Lv, JL; Yuan, HL; Yue, PF, 2013)		0.64
"In this study, a novel orodispersible film (ODF) containing drug nanoparticles was developed with the goal of transforming drug nanosuspensions into a solid dosage form and enhancing oral bioavailability of drugs with poor water solubility."( Development and characterization of an orodispersible film containing drug nanoparticles.
Bai, JX; Dai, L; Han, J; Lv, QY; Shen, BD; Shen, CY; Xu, H; Yu, C; Yuan, HL; Yuan, XD, 2013)		0.39
"The present study was designed to improve storage stability and oral bioavailability of Ganneng dropping pills (GNDP) by transforming lignans of Herpetospermum caudigerum (HL) composed of herpetrione (HPE) and herpetin (HPN) into nanosuspension (HL-NS), the main active ingredient of GNDP, HL-NS was prepared by high pressure homogenization and lyophilized to transform into solid nanoparticles (HL nanoparticles), and then the formulated HL nanoparticles were perfused into matrix to obtain NS-GNDP by melting method."( Improved stability and oral bioavailability of Ganneng dropping pills following transforming lignans of herpetospermum caudigerum into nanosuspensions.
Cheng, L; Li, JJ; Qiu, L; Shen, CY; Shen, G; Xu, R; Yuan, HL; Zheng, J, 2018)		0.67
"Nanotechnology has been a primary strategy to enhance oral bioavailability of poorly water soluble drugs."( Exploring the translocation behaviours
Hang, L; Shen, B; Shen, C; Wu, W; Xue, Y; Yuan, H, 2023)		0.91

Dosage Studied

ExcerptRelevanceReference
"In this study, a novel orodispersible film (ODF) containing drug nanoparticles was developed with the goal of transforming drug nanosuspensions into a solid dosage form and enhancing oral bioavailability of drugs with poor water solubility."( Development and characterization of an orodispersible film containing drug nanoparticles.
Bai, JX; Dai, L; Han, J; Lv, QY; Shen, BD; Shen, CY; Xu, H; Yu, C; Yuan, HL; Yuan, XD, 2013)		0.39
" The results demonstrated that uniformity of dosage units of NS-GNDP was acceptable according to the criteria of Chinese Pharmacopoeia 2015J."( Improved stability and oral bioavailability of Ganneng dropping pills following transforming lignans of herpetospermum caudigerum into nanosuspensions.
Cheng, L; Li, JJ; Qiu, L; Shen, CY; Shen, G; Xu, R; Yuan, HL; Zheng, J, 2018)		0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (85.71)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.48 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		2.520chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.1110dialdehydebiomarker
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.1710
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.5420
cellulose
DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.		2.0810glycoside
methylcellulose
Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Liver Injury, Drug-Induced
[description not available]		02.520
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		02.520