grayanotoxin ii

Description

grayanotoxin II: extract from leaves of Ericaceae; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Synonym
(1s,3r,4r,6s,8s,10s,13r,14r,16r)-5,5,14-trimethyl-9-methylidenetetracyclo[11.2.1.01,10.04,8]hexadecane-3,4,6,14,16-pentol
CHEBI:166677
4678-44-8
grayanotoxin ii
grayanotoxinii

The lethal dosage level of iso-grayanotoxin II in mice was lower than that of grayanotoxin III.

Excerpt	Relevance	Reference
" A dose-response curve for each GTX analog was constructed using depolarization as an index and assuming a simple one-to-one stoichiometry."	( Effect of structural modification of several groups on the D-ring of grayanotoxin on its depolarization potency in squid giant axon. Handa, S; Iwasa, J; Kamano, H; Kawanishi, T; Seyama, I; Tsuji, K, 1991)	0.28
" The lethal dosage level of iso-grayanotoxin II in mice was lower than that of grayanotoxin III."	( Isolation of iso-grayanotoxin II from leaves of Leucothoe grayana Max. Its X-ray crystallographic analysis and acute toxicity in mice. Araho, D; Katai, M; Katakawa, J; Matsuura, T; Narama, I; Osakabe, K; Sato, M; Terai, T; Tetsumi, T, 2000)	0.31
" The lethal dosage of 9alpha and 9beta-hydroxy grayanotoxin II were lower than that of grayanotoxin II."	( Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice. Katai, M; Katakawa, J; Matsuura, T; Narama, I; Osakabe, K; Sakaguchi, K; Terai, T; Tetsumi, T, 2003)	0.32

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Class	Description
tertiary alcohol	A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (18.18)	18.7374
1990's	2 (18.18)	18.2507
2000's	4 (36.36)	29.6817
2010's	3 (27.27)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (16.67%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
allethrins Allethrins: Synthetic analogs of the naturally occurring insecticides cinerin, jasmolin, and pyrethrin. (From Merck Index, 11th ed)	1.96	1	cyclopropanecarboxylate ester	pyrethroid ester insecticide
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.21	1	D-glucopyranose	epitope; mouse metabolite
taxine taxine: mixture of alkaloids isolated from Taxus baccata; structure in Merck Index	2.05	1
grayanotoxin i grayanotoxin I: RN given refers to (3beta,6beta,14R)-isomer; structure. grayanotoxin I : A tetracyclic diterpenoid that is grayanotoxane in which the pro-R hydrogen at position 14 is substituted by an acetoxy group and in which the 3beta-, 5-, 6beta-, 10-, and 16- positions are substituted by hydroxy groups.	3.09	5	acetate ester; pentol; secondary alcohol; tertiary alcohol; tetracyclic diterpenoid	antihypertensive agent; metabolite; neuromuscular agent; phytotoxin
grayanotoxin iii grayanotoxin III: from leaves of Leucothoe grayana (Ericaceae); RN refers to (3beta,6beta,14R)-isomer; structure given in first source	3.09	5

Condition	Relationship Strength	Studies
Bradyarrhythmia [description not available]	2.13	1
Food Poisoning [description not available]	2.13	1
Blood Pressure, Low [description not available]	2.13	1
Drop Attack [description not available]	2.13	1
Bradycardia Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.	2.13	1
Hypotension Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	2.13	1
Syncope A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)	2.13	1