Compounds > gratisin

Page last updated: 2024-10-15

gratisin

Description

gratisin: from Bacillus brevis; cyclodecapeptide; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	16132206
CHEMBL ID	556327
MeSH ID	M0103335

Synonyms (4)

Synonym
37294-30-7
gratisin
CHEMBL556327
(3r,6s,9s,12s,15r,18s,24r,27s,30s,33s,36r,39s)-9,30-bis(3-aminopropyl)-3,24-dibenzyl-15,36-bis[(4-hydroxyphenyl)methyl]-6,27-bis(2-methylpropyl)-12,33-di(propan-2-yl)-1,4,7,10,13,16,22,25,28,31,34,37-dodecazatricyclo[37.3.0.018,22]dotetracontane-2,5,8,11,

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay ID	Title	Year	Journal	Article
AID434703	Antibiotic activity against Bacillus megaterium ATCC 19213 by microplate dilution assay	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Syntheses of low-hemolytic antimicrobial gratisin peptides.
AID434707	Antibiotic activity against Escherichia coli NBRC 12734 by microplate dilution assay	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Syntheses of low-hemolytic antimicrobial gratisin peptides.
AID551040	Antibacterial activity against Escherichia coli NBRC l2734 after overnight incubation by medium dilution method	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity.
AID551041	Cytotoxicity against human RBC assessed induction of hemolysis at 100 uL after 30 mins microtiter plate reader analysis	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity.
AID551037	Antibacterial activity against Staphylococcus epidermidis NBRC 12993 after overnight incubation by medium dilution method	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity.
AID434705	Antibiotic activity against Staphylococcus aureus NBRC 12732 by microplate dilution assay	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Syntheses of low-hemolytic antimicrobial gratisin peptides.
AID434706	Antibiotic activity against Pseudomonas aeruginosa NBRC 3080 by microplate dilution assay	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Syntheses of low-hemolytic antimicrobial gratisin peptides.
AID434708	Cytotoxicity against human red blood cells assessed as hemolysis after 30 mins	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Syntheses of low-hemolytic antimicrobial gratisin peptides.
AID551036	Antibacterial activity against Bacillus megaterium ATCC 19213 after overnight incubation by medium dilution method	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity.
AID434704	Antibiotic activity against Staphylococcus epidermidis NBRC 12933 by microplate dilution assay	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Syntheses of low-hemolytic antimicrobial gratisin peptides.
AID551039	Antibacterial activity against Pseudomonas aeruginosa NBRC 3080 after overnight incubation by medium dilution method	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity.
AID551038	Antibacterial activity against Staphylococcus aureus NBRC 12732 after overnight incubation by medium dilution method	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity.
AID434702	Antibiotic activity against Bacillus subtilis NBRC 3513 by microplate dilution assay	2009	Bioorganic & medicinal chemistry letters, May-15, Volume: 19, Issue:10	Syntheses of low-hemolytic antimicrobial gratisin peptides.
AID551035	Antibacterial activity against Bacillus subtilis NBRC 3513 after overnight incubation by medium dilution method	2011	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1	Novel gratisin derivatives with high antimicrobial activity and low hemolytic activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (33.33)	18.7374
1990's	1 (11.11)	18.2507
2000's	3 (33.33)	29.6817
2010's	2 (22.22)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
gramicidin s [no description available]	2.05	1	0	homodetic cyclic peptide
gramicidin a Gramicidin: A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.	2.39	2	0

Condition	Indicated	Relationship Strength	Studies	Trials
Extravascular Hemolysis [description not available]	0	2.75	3	0
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	0	2.75	3	0