grandisine D: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 16040172 |
| CHEMBL ID | 612043 |
| MeSH ID | M0543220 |
| Synonym |
|---|
| grandisine d |
| CHEMBL612043 |
| (5s,6r)-6-[(8as)-1,2,3,5,6,8a-hexahydroindolizine-8-carbonyl]-5-methylcyclohex-2-en-1-one |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | Homo sapiens (human) | IC50 (µMol) | 1.6500 | 0.0002 | 0.7521 | 8.0140 | AID378465 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| G protein-coupled opioid receptor activity | Delta-type opioid receptor | Homo sapiens (human) |
| protein binding | Delta-type opioid receptor | Homo sapiens (human) |
| receptor serine/threonine kinase binding | Delta-type opioid receptor | Homo sapiens (human) |
| G protein-coupled enkephalin receptor activity | Delta-type opioid receptor | Homo sapiens (human) |
| neuropeptide binding | Delta-type opioid receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Delta-type opioid receptor | Homo sapiens (human) |
| synaptic vesicle membrane | Delta-type opioid receptor | Homo sapiens (human) |
| dendrite membrane | Delta-type opioid receptor | Homo sapiens (human) |
| presynaptic membrane | Delta-type opioid receptor | Homo sapiens (human) |
| axon terminus | Delta-type opioid receptor | Homo sapiens (human) |
| spine apparatus | Delta-type opioid receptor | Homo sapiens (human) |
| postsynaptic density membrane | Delta-type opioid receptor | Homo sapiens (human) |
| neuronal dense core vesicle | Delta-type opioid receptor | Homo sapiens (human) |
| plasma membrane | Delta-type opioid receptor | Homo sapiens (human) |
| neuron projection | Delta-type opioid receptor | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID378465 | Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK293 cells | 2006 | Journal of natural products, Sep, Volume: 69, Issue:9 | Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.63) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||