Compounds > gnidimacrin

Page last updated: 2024-11-08

gnidimacrin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

gnidimacrin: a daphnane-type orthoester diterpene similar in structure to phorbols; antileukemic; found in Gnidia, Stellera, Pimelea; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Stellera	genus	[no description available]	Thymelaeaceae	A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]
Gnidia	genus	[no description available]	Thymelaeaceae	A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]

Cross-References

ID Source	ID
PubMed CID	3085204
CHEMBL ID	4786738
MeSH ID	M0060427

Synonyms (5)

Synonym
60796-70-5
gnidimacrin
[benzoyloxy-trihydroxy-(hydroxymethyl)-isopropenyl-dimethyl-[?]yl]methyl benzoate
CHEMBL4786738
[(1r,2s,4r,5r,6s,7s,9r,10s,11s,12s,13s,14s,15r,22r,23s,25r)-12-benzoyloxy-10,11,22-trihydroxy-9-(hydroxymethyl)-13,15-dimethyl-4-prop-1-en-2-yl-8,24,26,27-tetraoxaheptacyclo[12.10.1.14,23.15,23.01,6.07,9.011,25]heptacosan-2-yl]methyl benzoate

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1718300	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	2020	Journal of natural products, 12-24, Volume: 83, Issue:12	Anti-HIV Tigliane Diterpenoids from
AID1718299	Antiviral activity against HIV-1 NL4-3 infected in human MT4 cells assessed as reduction in p24 gag protein expression incubated for 48 hrs by ELISA	2020	Journal of natural products, 12-24, Volume: 83, Issue:12	Anti-HIV Tigliane Diterpenoids from
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (15.38)	18.7374
1990's	3 (23.08)	18.2507
2000's	4 (30.77)	29.6817
2010's	3 (23.08)	24.3611
2020's	1 (7.69)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.69%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (92.31%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
thiazoles [no description available]	2	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
phorbol 12,13-dibutyrate Phorbol 12,13-Dibutyrate: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.	1.99	1	0	butyrate ester; phorbol ester; tertiary alpha-hydroxy ketone
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2	1	0	organic bromide salt	colorimetric reagent; dye
teleocidin b-4 teleocidins: structure; RN given refers to teleocidin	1.96	1	0
ingenol [no description available]	1.96	1	0	cyclic terpene ketone; tetracyclic diterpenoid
bryostatin 1 bryostatin 1: a protein kinase C activator; macrocyclic lactone from marine Bryozoan Bugula neritina; RN given refers to (1S-(1R,3R,5Z,7S,8E,11R,12R(2E,4E),13E,15R,17S(S),21S,23S,25R))-isomer; structure given in first source; activates protein kinase c. bryostatin 1 : A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.	3.53	2	0

Condition	Indicated	Relationship Strength	Studies	Trials
HIV Coinfection [description not available]	0	2.11	1	0
HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	0	2.11	1	0
Degenerative Diseases, Central Nervous System [description not available]	0	2.96	1	0
Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	0	2.96	1	0
Hepatocellular Carcinoma [description not available]	0	2.05	1	0
Cancer of Liver [description not available]	0	2.05	1	0
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	0	2.05	1	0
Liver Neoplasms Tumors or cancer of the LIVER.	0	2.05	1	0
Carcinoma, Oat Cell [description not available]	0	2.01	1	0
Cancer of Lung [description not available]	0	2.01	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	0	2.01	1	0
Carcinoma, Small Cell An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)	0	2.01	1	0
Carcinoma, Lewis Lung A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	0	1.98	1	0
Experimental Leukemia [description not available]	0	1.98	1	0
B16 Melanoma [description not available]	0	1.98	1	0