Page last updated: 2024-12-08

glycyl-prolyl-arginine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID170776
CHEMBL ID3752079
CHEBI ID163949
SCHEMBL ID7853147
MeSH IDM0107567

Synonyms (15)

Synonym
GPR ,
glycylprolylarginine
(2s)-2-[[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
glycyl-prolyl-arginine
47295-77-2
l-arginine, n2-(1-glycyl-l-prolyl)-
gly-pro-arg
SCHEMBL7853147
CHEMBL3752079
DTXSID00197085
g-p-r
glycyl-l-prolyl-l-arginine
CHEBI:163949
CS-0615404
HY-P3528
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oligopeptideA peptide containing a relatively small number of amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1272142Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neurotoxicity in human SH-SY5Y cells assessed as NO production per 10'6 cells at 10 nM for 1 hr followed by addition of THP1 conditioned medium by griess assay (Rvb = 3.75 +/- 02016European journal of medicinal chemistry, Jan-27, Volume: 108Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties.
AID1272143Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neurotoxicity in human SH-SY5Y cells assessed as NO production per 10'6 cells at 100 nM for 1 hr followed by addition of THP1 conditioned medium by griess assay (Rvb = 3.75 +/- 2016European journal of medicinal chemistry, Jan-27, Volume: 108Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties.
AID1272145Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neurotoxicity in human SH-SY5Y cells assessed as NO production per 10'6 cells at 10 uM for 1 hr followed by addition of THP1 conditioned medium by griess assay (Rvb = 3.75 +/- 02016European journal of medicinal chemistry, Jan-27, Volume: 108Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties.
AID1272138Metabolic stability in human plasma assessed as half life by HPLC analysis2016European journal of medicinal chemistry, Jan-27, Volume: 108Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties.
AID1272144Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neurotoxicity in human SH-SY5Y cells assessed as NO production per 10'6 cells at 1 uM for 1 hr followed by addition of THP1 conditioned medium by griess assay (Rvb = 3.75 +/- 0.2016European journal of medicinal chemistry, Jan-27, Volume: 108Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties.
AID1272146Neuroprotective against IFNgamma/LPS stimulated THP1 condition medium-induced neurotoxicity in human SH-SY5Y cells assessed as NO production per 10'6 cells at 100 uM for 1 hr followed by addition of THP1 conditioned medium by griess assay (Rvb = 3.75 +/- 2016European journal of medicinal chemistry, Jan-27, Volume: 108Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (13.33)18.7374
1990's5 (33.33)18.2507
2000's1 (6.67)29.6817
2010's7 (46.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.59 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index5.48 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]