glutaric anhydride profile

Glutaric anhydride is a cyclic anhydride derived from glutaric acid. It is a white crystalline solid with a melting point of 56-57 °C. Glutaric anhydride is commonly used as a reagent in organic synthesis. It is a valuable starting material for the preparation of various important compounds, including pharmaceuticals, polymers, and other fine chemicals. Its synthesis typically involves the dehydration of glutaric acid using methods like heating under reduced pressure or using dehydrating agents. Glutaric anhydride has been investigated for its potential applications in various fields. For example, it has been studied as a precursor for the synthesis of polyesters, which are valuable polymers with diverse applications. Additionally, glutaric anhydride has been explored as a building block for the synthesis of pharmaceutical compounds with diverse biological activities. The importance of glutaric anhydride lies in its versatility as a synthetic intermediate and its potential applications in diverse fields, making it a subject of continued research and development.'

glutaric anhydride: RN given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

glutaric anhydride : A cyclic dicarboxylic anhydride that is oxane which carries oxo groups at positions 2 and 6. It is used as an intermediate in the production of pharmaceuticals, corrosion inhibitors, and polymers (E.g. epoxy polyesters). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	7940
CHEMBL ID	3188341
CHEBI ID	167482
SCHEMBL ID	19926
MeSH ID	M0213149

Synonym
CHEBI:167482
oxane-2,6-dione
pentanedioic acid anhydride
tetrahydropyran-2,6-dione
pyroglutaric acid
2h-pyran-2,6(3h)-dione, dihydro
ai3-06352
einecs 203-593-6
nsc 16640
brn 0110051
anhydrid kyseliny glutarove [czech]
glutaric anhydride
2h-pyran-2, dihydro-
nsc-16640
wln: t6vovtj
glutaric acid anhydride
nsc16640
108-55-4
pentanedioic anhydride
2h-pyran-2,6(3h)-dione, dihydro-
inchi=1/c5h6o3/c6-4-2-1-3-5(7)8-4/h1-3h
dihydro-2h-pyran-2,6(3h)-dione
glutaric anhydride, 95%
STK397450
G0071
AKOS000121028
tetrahydropyran-2,6-dione;dihydro-2h-pyran-2,6(3h)-dione
A801892
NCGC00248238-01
cas-108-55-4
NCGC00254877-01
dtxsid5044362 ,
dtxcid3024362
tox21_300975
unii-63ofi15s80
63ofi15s80 ,
anhydrid kyseliny glutarove
ec 203-593-6
5-17-11-00009 (beilstein handbook reference)
BP-13001
FT-0626733
oxacyclohexane-2,6-dione
dihydro-3h-pyran-2,6-dione
pentahydropyran-2,6-dione
dihydropyran-2,6-dione
SCHEMBL19926
dihydro-pyran-2,6-dione
Q-201164
pentanedioic-d6 anhydride
1219794-53-2
CHEMBL3188341
mfcd00006679
F0001-0173
glutaric anhydride, technical, >=90% (nt)
glutaric anhydride, vetec(tm) reagent grade, 94%
AS-13081
Q11074437
AM1000009
EN300-18018

Excerpt	Relevance	Reference
" Dilution with water given by gavage after peroral dosing had no effect on lethal toxicity."	( The acute toxicity, primary irritancy and skin sensitizing potential of glutaric anhydride. Ballantyne, B; Blaszcak, DL; Myers, RC, 1992)	0.52

Class	Description
cyclic dicarboxylic anhydride	An acid anhydride derived by loss of water between two carboxylic groups in the same molecule so as to close a ring.
oxanes	Any organic heteromonocyclic compoundthat is oxane or its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	48.5577	0.0006	27.2152	1,122.0200	AID743202; AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (5.56)	18.7374
1990's	2 (11.11)	18.2507
2000's	6 (33.33)	29.6817
2010's	5 (27.78)	24.3611
2020's	4 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	2	1	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
glutaric acid glutaric acid: RN given refers to parent cpd. glutaric acid : An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.	2.6	1	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	Daphnia magna metabolite; human metabolite
melatonin [no description available]	2.25	1	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.07	1	metal allergen; nickel group element atom	epitope; micronutrient
hydroxide ion [no description available]	2	1	oxygen hydride	mouse metabolite
cystamine [no description available]	2.07	1	organic disulfide; primary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.25	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
mesalamine Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed). mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.	2.06	1	amino acid; aromatic amine; monocarboxylic acid; monohydroxybenzoic acid; phenols	non-steroidal anti-inflammatory drug
estrone Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.	6.93	1	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite
trifluoroacetic acid Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.	2	1	fluoroalkanoic acid	human xenobiotic metabolite; NMR chemical shift reference compound; reagent
anisole anisole : A monomethoxybenzene that is benzene substituted by a methoxy group.	6.93	1	monomethoxybenzene	plant metabolite
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	1.98	1	fluorescein isothiocyanate
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	7.03	1	cobalt group element atom
galactosamine 2-amino-2-deoxy-D-galactopyranose : The pyranose form of D-galactosamine.. D-galactosamine : The D-stereoisomer of galactosamine.	2.07	1	D-galactosamine; primary amino compound	toxin
pyrene pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.	2.1	1	ortho- and peri-fused polycyclic arene	fluorescent probe; persistent organic pollutant
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	2.07	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
ractopamine ractopamine: veterinary growth stimulant. ractopamine : A diastereoisomeric mixture of approximately equal amounts of all four possible diastereoisomers of 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol. A beta-adrenergic agonist, it is used (generally as the hydrochloride salt) as a feed additive for use in pigs and other livestock to promote protein deposition, resulting in leaner meat. The R,R diastereoisomer, butopamine, is responsible for most of the leanness-enhancing effects. While use of ractopamine has been banned in over 120 countries including throughout the EU, in the US it used in an estimated 80% of all beef, pork and turkey production.. 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol : A secondary amino compound that is 4-(2-amino-1-hydroxyethyl)phenol in which one of the hydrogens attached to the nitrogen is replaced by a 4-(p-hydroxyphenyl)butan-2-yl group.	2	1	benzyl alcohols; polyphenol; secondary alcohol; secondary amino compound
lamivudine [no description available]	2.03	1	monothioacetal; nucleoside analogue; oxacycle; primary alcohol	allergen; anti-HBV agent; antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor; HIV-1 reverse transcriptase inhibitor; prodrug
n-hydroxysuccinimide N-hydroxysuccinimide: structure	2.01	1
3-(trimethoxysilyl)propylamine 3-(trimethoxysilyl)propylamine: reagent for making polymers; structure in first source	2.08	1
succinimidyl 4-(4-maleimidophenyl)butyrate succinimidyl 4-(4-maleimidophenyl)butyrate: structure given in first source	2.03	1
carbodiimides Carbodiimides: Compounds with the general formula RN=C=NR, where R is a hydrocarbyl group.. methanediimine : A carbodiimide in which both nitrogens are unsubstituted.	2.07	1	carbodiimide
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2	1	cyclodextrin
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.1	1
pulmicort Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.. budesonide : A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.	2.06	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; cyclic acetal; glucocorticoid; primary alpha-hydroxy ketone	anti-inflammatory drug; bronchodilator agent; drug allergen
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	2.08	1	carbon group element atom; metalloid atom; nonmetal atom
oligonucleotides [no description available]	2.08	1
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	7.6	1	glycoside
agar Agar: A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.. agar : A complex mixture of polysaccharides extracted from species of red algae. Its two main components are agarose and agaropectin. Agarose is the component responsible for the high-strength gelling properties of agar, while agaropectin provides the viscous properties.	7.6	1

Condition	Relationship Strength	Studies
Candida Infection [description not available]	2.25	1
Anasarca [description not available]	2.25	1
Mucositis, Oral [description not available]	2.25	1
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.25	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.25	1
Stomatitis INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.	2.25	1
Benign Neoplasms [description not available]	2.1	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.1	1
Colitis Gravis [description not available]	2.06	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.06	1
Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	2.06	1
Sarcoma 180 An experimental sarcoma of mice.	1.98	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.41	2
Contact Dermatitis [description not available]	1.98	1
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	1.98	1
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	1.98	1

glutaric anhydride

Description

Cross-References

Synonyms (59)

Research Excerpts

Dosage Studied

Drug Classes (2)

Protein Targets (1)

Potency Measurements

Research

Studies (18)

Market Indicators

Research Demand Index: 46.80

Study Types