Compounds > fluorosalinosporamide
Page last updated: 2024-11-13

fluorosalinosporamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

fluorosalinosporamide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24882226
CHEMBL ID514721
MeSH IDM0522861

Synonyms (3)

Synonym
CHEMBL514721
fluorosalinosporamide
(1r,4r,5s)-1-[(s)-[(1s)-cyclohex-2-en-1-yl]-hydroxymethyl]-4-(2-fluoroethyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID390500Inhibition of caspase-like activity of rabbit 20S proteasome2008Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
AID390499Inhibition of trypsin-like activity of rabbit 20S proteasome2008Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
AID390498Inhibition of chymotrypsin-like activity of rabbit 20S proteasome2008Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
AID390497Stability in 20 mM HEPES buffer assessed as beta-lactone hydrolysis rate at pH 7.3 at 27 degC2008Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
AID390507Inhibition of chymotrypsin-like activity of rabbit 20S proteasome assessed as enzyme activity recovery 24 hrs after dialysis2008Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0510halide anion;
monoatomic bromine
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0410pyrrole;
secondary amine
acetyl coenzyme a
Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.		3.2110acyl-CoAacyl donor;
coenzyme;
effector;
fundamental metabolite
salinosporamide b
salinosporamide B: from the marine Actinomycete Salinispora tropica; structure in first source		2.4420salinosporamide
marizomib
marizomib: a proteasome inhibitor from a marine bacterium Salinospora; structure in first source		2.4420beta-lactone;
gamma-lactam;
organic heterobicyclic compound;
organochlorine compound;
salinosporamide		antineoplastic agent;
proteasome inhibitor
fluoroacetyl-coenzyme a
fluoroacetyl-CoA : An acyl-CoA that results from the formal condensation of the thiol group of Co-A with the carboxylic acid group of fluoroacetic acid.		3.2110haloacyl-CoA
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Skin
[description not available]		03.0310
Skin Neoplasms
Tumors or cancer of the SKIN.		03.0310