feruloyl-coa

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

feruloyl-CoA(4-) : An acyl-CoA(4-) that is the tetraanion of feruloyl-CoA arising from deprotonation of the phosphate and diphosphate OH groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

trans-feruloyl-CoA(4-) : An acyl-CoA(4-) obtained by deprotonation of the phosphate and diphosphate OH groups of 3-trans-feruloyl-CoA. Major structure at pH 7.3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	44229137
CHEBI ID	57276
CHEBI ID	87305
MeSH ID	M0305189

Synonyms (19)

Synonym
feruloyl-coa tetraanion
CHEBI:57276
feruloyl-coa(4-)
feruloyl-coenzyme a(4-)
3'-phosphonatoadenosine 5'-{3-[(3r)-3-hydroxy-4-({3-[(2-{[3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-2,2-dimethyl-4-oxobutyl] diphosphate}
4-hydroxy-3-methoxycinnamoyl-coa(4-)
feruloyl-coa ,
(e)-4-hydroxy-3-methoxycinnamoyl-coa
(e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl-coa
trans-feruloyl-coa(4-)
trans-4-hydroxy-3-methoxycinnamoyl-coa(4-)
CHEBI:87305
(e)-feruloyl-coa
trans-feruloyl-coenzyme a(4-)
(e)-feruloyl-coa(4-)
(e)-feruloyl-coenzyme a(4-)
trans-4-hydroxy-3-methoxycinnamoyl-coenzyme a(4-)
LMFA07050319
Q27159512

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
feruloyl-CoA(4-)	An acyl-CoA(4-) that is the tetraanion of feruloyl-CoA arising from deprotonation of the phosphate and diphosphate OH groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (18)

Pathway	Proteins	Compounds
spermidine hydroxycinnamic acid conjugates biosynthesis	4	14
phenylpropanoids methylation (ice plant)	1	25
suberin monomers biosynthesis	10	36
chlorogenic acid biosynthesis I	6	15
curcuminoid biosynthesis	4	19
hydroxycinnamic acid serotonin amides biosynthesis	0	17
flavonol acylglucoside biosynthesis I - kaempferol derivatives	0	9
esterified suberin biosynthesis	1	4
scopoletin biosynthesis	4	11
coumarins biosynthesis (engineered)	6	28
phenylpropanoid biosynthesis	16	28
hydroxycinnamic acid tyramine amides biosynthesis	0	21
capsiconiate biosynthesis	1	11
flavonol acylglucoside biosynthesis III - quercetin derivatives	0	8
capsaicin biosynthesis	6	16
flavonol acylglucoside biosynthesis II - isorhamnetin derivatives	0	7
flavonol acylglucoside biosynthesis II - isorhamnetin derivatives	0	13
scopoletin biosynthesis	5	15
esterified suberin biosynthesis	0	4
suberin monomers biosynthesis	13	42
coumarins biosynthesis (engineered)	8	31
ferulate degradation	3	10
spermidine hydroxycinnamic acid conjugates biosynthesis	3	15
phenylpropanoid biosynthesis	12	29
flavonol acylglucoside biosynthesis III - quercetin derivatives	0	14
flavonol acylglucoside biosynthesis I - kaempferol derivatives	0	15
suberin biosynthesis	0	29

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.76)	18.2507
2000's	10 (47.62)	29.6817
2010's	5 (23.81)	24.3611
2020's	5 (23.81)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	26.64 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	5.06 (4.65)
Search Engine Demand Index	29.35 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (26.64)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
3-hydroxybenzaldehyde [no description available]	2.6	1	hydroxybenzaldehyde
phosphoric acid phosphoric acid: concise etchant is 37% H3PO4. phosphoric acid : A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.	2	1	phosphoric acids	algal metabolite; fertilizer; human metabolite; NMR chemical shift reference compound; solvent
vanillin Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).	8.34	6	benzaldehydes; monomethoxybenzene; phenols	anti-inflammatory agent; anticonvulsant; antioxidant; flavouring agent; plant metabolite
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2	1	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
vanillic acid Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.	2	1	methoxybenzoic acid; monohydroxybenzoic acid	plant metabolite
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.04	1	D-glucopyranose	epitope; mouse metabolite
dihydrochalcone dihydrochalcone : A member of the class of dihydrochalcones that is acetophenone in which one of the hydrogens of the methyl group is replaced by a benzyl group.	2.1	1	dihydrochalcones	plant metabolite
benzoyl-coenzyme a benzoyl-coenzyme A: RN given refers to unlabeled cpd	2.01	1
lignin Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.	8.05	4
organophosphonates hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.	2.02	1	divalent inorganic anion; phosphite ion
scopolin [no description available]	2.04	1	beta-D-glucoside; coumarins; monosaccharide derivative	plant metabolite
acetyl coenzyme a Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.	2.04	1	acyl-CoA	acyl donor; coenzyme; effector; fundamental metabolite
ferulic acid ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.	2.73	3	ferulic acids	anti-inflammatory agent; antioxidant; apoptosis inhibitor; cardioprotective agent; MALDI matrix material; plant metabolite
5-hydroxyferulic acid 5-hydroxyferulic acid : Ferulic acid in which the ring hydrogen at position 5 is substituted by a hydroxy group.. (E)-5-hydroxyferulic acid : The E-isomer of 5-hydroxyferulic acid.	2.01	1	5-hydroxyferulic acid
malonyl coenzyme a Malonyl Coenzyme A: A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.. omega-carboxyacyl-CoA : An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of any alpha,omega-dicarboxylic acid.	2.05	1	malonyl-CoAs	EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor; Escherichia coli metabolite; metabolite; mouse metabolite
caffeic acid trans-caffeic acid : The trans-isomer of caffeic acid.	2.01	1	caffeic acid	geroprotector; mouse metabolite
nadp [no description available]	2.52	2
scopoletin [no description available]	2.46	2	hydroxycoumarin	plant growth regulator; plant metabolite
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.07	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite
caffeoyl-coenzyme a caffeoyl-coenzyme A: structure given in first source	3.12	5
4-coumaroyl-coenzyme a 4-coumaroyl-coenzyme A: structure given in first source. trans-4-coumaroyl-CoA : A 4-coumaroyl-CoA in which the double bond of the coumaroyl group has trans-geochemistry.. 4-coumaroyl-CoA : The S-(4-coumaroyl) derivative of coenzyme A.	3.28	6	4-coumaroyl-CoA
cinnamoyl-coenzyme a (E)-cinnamoyl-CoA : The (E)-isomer of cinnamoyl-CoA.	2.94	4	cinnamoyl-CoA
chitosan [no description available]	2.07	1
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	2	1	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.8	3	benzenes; hydroxycoumarin; methyl ketone

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