Compounds > fenoxedil
Page last updated: 2024-12-06

fenoxedil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Fenoxedil is a synthetic vasodilator that acts as a calcium channel blocker and has anti-inflammatory properties. It is studied for its potential therapeutic effects in treating cardiovascular diseases, particularly peripheral artery disease (PAD), and its anti-inflammatory properties have been investigated in relation to various conditions, including arthritis and cancer. It is also known to have antioxidant effects. Its mechanism of action involves inhibiting the influx of calcium ions into smooth muscle cells, leading to vasodilation and improved blood flow. However, it is not widely used in clinical practice due to its potential side effects and limited evidence of its efficacy. '

fenoxedil: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID71731
CHEMBL ID2104319
CHEBI ID135786
SCHEMBL ID554703
MeSH IDM0056463

Synonyms (16)

Synonym
fenoxedil
CHEBI:135786
CHEMBL2104319
fenoxedilum [inn-latin]
fenoxedil [inn:dcf]
fenoxedilum
unii-abx8234h6m
abx8234h6m ,
2-(p-butoxyphenoxy)-n-(2,5-diethoxyphenyl)-n-(2-(diethylamino)ethyl)acetamide
54063-40-0
SCHEMBL554703
fenoxedil [mi]
fenoxedil [inn]
DTXSID50202390
2-(4-butoxyphenoxy)-n-(2,5-diethoxyphenyl)-n-[2-(diethylamino)ethyl]acetamide
Q27273850
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
anilideAny aromatic amide obtained by acylation of aniline.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.25 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
ConditionIndicatedRelationship StrengthStudiesTrials
Arrhythmia
[description not available]		08.0550
Arrhythmias, Cardiac
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.		03.0550
Auricular Fibrillation
[description not available]		02.6530
Atrial Fibrillation
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.		07.6530
Auricular Flutter
[description not available]		01.9510
Cardiac Complex, Premature
[description not available]		01.9510
Atrial Flutter
Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).		01.9510
A-V Dissociation
[description not available]		01.9510
Brain Vascular Disorders
[description not available]		01.9510
Cerebrovascular Disorders
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.		01.9510