Page last updated: 2024-12-06
fenoxedil
Description
Fenoxedil is a synthetic vasodilator that acts as a calcium channel blocker and has anti-inflammatory properties. It is studied for its potential therapeutic effects in treating cardiovascular diseases, particularly peripheral artery disease (PAD), and its anti-inflammatory properties have been investigated in relation to various conditions, including arthritis and cancer. It is also known to have antioxidant effects. Its mechanism of action involves inhibiting the influx of calcium ions into smooth muscle cells, leading to vasodilation and improved blood flow. However, it is not widely used in clinical practice due to its potential side effects and limited evidence of its efficacy. '
fenoxedil: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 71731 |
| CHEMBL ID | 2104319 |
| CHEBI ID | 135786 |
| SCHEMBL ID | 554703 |
| MeSH ID | M0056463 |
Synonyms (16)
| Synonym |
|---|
| fenoxedil |
| CHEBI:135786 |
| CHEMBL2104319 |
| fenoxedilum [inn-latin] |
| fenoxedil [inn:dcf] |
| fenoxedilum |
| unii-abx8234h6m |
| abx8234h6m , |
| 2-(p-butoxyphenoxy)-n-(2,5-diethoxyphenyl)-n-(2-(diethylamino)ethyl)acetamide |
| 54063-40-0 |
| SCHEMBL554703 |
| fenoxedil [mi] |
| fenoxedil [inn] |
| DTXSID50202390 |
| 2-(4-butoxyphenoxy)-n-(2,5-diethoxyphenyl)-n-[2-(diethylamino)ethyl]acetamide |
| Q27273850 |
Drug Classes (1)
| Class | Description |
|---|
| anilide | Any aromatic amide obtained by acylation of aniline. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.25
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.25 (24.57) | | Research Supply Index | 2.20 (2.92) | | Research Growth Index | 4.45 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |