euphorbia factor l1 profile

euphorbia factor L1: reverses ABCB1-mediated multidrug resistance; isolated from Euphorbia; struture in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	11238221
CHEMBL ID	553622
MeSH ID	M0559560

Synonym
CHEMBL553622
euphorbiasteroid
76376-43-7
euphorbia-factor-l1
euphorbia factor l1
HY-N2557
[(1'r,2s,3'e,5'r,7's,11'r,12'r,13's,14's)-1',11'-diacetyloxy-3',6',6',14'-tetramethyl-2'-oxospiro[oxirane-2,10'-tricyclo[10.3.0.05,7]pentadec-3-ene]-13'-yl] 2-phenylacetate
CS-0022889

Excerpt	Reference	Relevance
"Euphorbia factor L1 (EFL1) is a lathyrane-type diterpenoid from the medicinal herb Euphorbia lathyris L., and has been reported with intestinal toxicity, but the potential mechanisms remain unknown."	( Effect of Euphorbia factor L1 on intestinal barrier impairment and defecation dysfunction in Caenorhabditis elegans. Gao, S; Ji, Z; Li, G; Sun, Y; Wang, Q; Zhang, T; Zhang, W; Zhao, J; Zhu, A, 2019)	2.36

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID1639046	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by CCK8 assay	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Anti-inflammatory Lathyrane Diterpenoids from Euphorbia lathyris.
AID1639045	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 3 hrs followed by LPS-stimulation and measured after 24 hrs by Griess assay	2019	Journal of natural products, 04-26, Volume: 82, Issue:4	Anti-inflammatory Lathyrane Diterpenoids from Euphorbia lathyris.
AID429846	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.
AID429848	Reversal of p-gp-mediated multidrug-resistance in human MCF7/ADM cells after 48 hrs by SRB assay	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.
AID429847	Reversal of p-gp-mediated multidrug-resistance in human MCF7/ADM cells assessed as enhancement intensity at 10 ug/mL after 48 hrs by SRB assay relative to adriamycin	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.
AID429850	Octanol-water partition coefficient, log P of the compound	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.
AID429849	Reversal of P-gp-mediated multidrug resistance in human MCF/ADR cells assessed as reversal fold after 48 hrs by SRB assay relative to control	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.
AID1901281	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	2022	Bioorganic & medicinal chemistry, 02-15, Volume: 56	Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (6.25)	29.6817
2010's	9 (56.25)	24.3611
2020's	6 (37.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.05	1	aromatic ether; nitrile; polyether; tertiary amino compound
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	2.17	1	alkane
n-hexane hexane : An unbranched alkane containing six carbon atoms.	2.17	1	alkane; volatile organic compound	neurotoxin; non-polar solvent
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.41	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
rhodamine 123 Rhodamine 123: A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30). rhodamine 123(1+) : A cationic fluorescent dye derived from 9-phenylxanthene.	2.06	1	organic cation; xanthene dye	fluorochrome
diacetyl benzoyl lathyrol [no description available]	2.83	3	diterpenoid

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	2.05	1
Carcinoma, Anaplastic [description not available]	2.05	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.05	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.05	1
Carcinoma, Non-Small Cell Lung [description not available]	2.41	1
Cancer of Lung [description not available]	2.41	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.41	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.41	1
Sarcoma, Epithelioid [description not available]	2.05	1
Cancer of the Uterus [description not available]	2.05	1
Sarcoma A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.	2.05	1
Uterine Neoplasms Tumors or cancer of the UTERUS.	2.05	1
Adenocarcinoma, Basal Cell [description not available]	2.9	2
Cancer of Colon [description not available]	2.9	2
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	7.9	2
Colonic Neoplasms Tumors or cancer of the COLON.	2.9	2
Dysplastic Nevus Syndrome, Hereditary [description not available]	2.6	1
Cancer of Liver [description not available]	2.6	1
Malignant Melanoma [description not available]	2.6	1
Cancer, Second Primary [description not available]	2.6	1
Ascites Accumulation or retention of free fluid within the peritoneal cavity.	2.6	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.6	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.6	1
Bone Loss, Osteoclastic [description not available]	2.15	1

euphorbia factor l1

Description

Cross-References

Synonyms (8)

Research Excerpts

Overview

Bioassays (8)

Research

Studies (16)

Market Indicators

Research Demand Index: 12.32

Study Types

euphorbia factor l1

Description

Cross-References

Synonyms (8)

Research Excerpts

Overview

Bioassays (8)

Research

Studies (16)

Market Indicators

Research Demand Index: 12.32

Study Types

Related Drugs (6)

Related Conditions (24)