Page last updated: 2024-12-08

etilefrine hydrochloride

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID164652
CHEMBL ID3187408
CHEBI ID31582
SCHEMBL ID207591
MeSH IDM0330371

Synonyms (87)

Synonym
bioflutin
etilefrine hcl
cardanat
efortil
etilefrin hydrochloride
534-87-2
(+-)-n-ethylnorphenylephrine hydrochloride
(+-)-ethylphenylephrine hydrochloride
zbi6q5fh3s ,
etilefrine hydrochloride [jan]
unii-zbi6q5fh3s
dl-effortil hydrochloride
pulsamin
kertasin
eti-puren
1-(3-hydroxyphenyl)-2-ethylaminoethanol hydrochloride
dl-1-(3-hydroxyphenyl)-1-hydroxy-2-ethylaminoethane hydrochloride
thomasin
einecs 213-398-8
benzenemethanol, alpha-((ethylamino)methyl)-3-hydroxy-, hydrochloride
circupon
effortilvet
apocretin
alpha-((ethylamino)methyl)-m-hydroxybenzyl alcohol hydrochloride
benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-, hydrochloride
dl-etilefrin hydrochloride
tonus-forte
dl-1-(3-hydroxyphenyl-2-ethylaminoethanol hydrochloride
dl-ethylphenylephrine hydrochloride
phetasin
dl-n-ethylnorphenylephrine hydrochloride
NCGC00016496-01
cas-534-87-2
phetanol
updormin
ethyl adrianol
etilefrine hydrochloride
funasol
effontil
ethylephrine hydrochloride
D01573
etilefrine hydrochloride (tn)
etilefrine hydrochloride (jp17)
943-17-9
FT-0668420
E0381
2-ethylamino-1-(3-hydroxyphenyl)ethanol hydrochloride
HMS1571K15
A844915
3-[2-(ethylamino)-1-hydroxy-ethyl]phenol hydrochloride
AKOS005267166
3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride
EN300-03375
dtxsid1045322 ,
dtxcid9025322
tox21_110457
FT-0603527
(+/-)-ethylphenylephrine hydrochloride
SCHEMBL207591
(rs)-2-ethylamino-1-(3-hydroxyphenyl)ethanol monohydrochloride
benzenemethanol, .alpha.-((ethylamino)methyl)-3-hydroxy-, hydrochloride (1:1)
(+/-)-n-ethylnorphenylephrine hydrochloride
ethylphenylephrine hydrochloride, dl-
etilefrin hydrochloride [mi]
etilefrine hydrochloride [mart.]
benzyl alcohol, .alpha.-((ethylamino)methyl)-m-hydroxy-, hydrochloride
etilefrine hydrochloride [ep monograph]
etilefrine hydrochloride [who-dd]
ethlyphenylephrine hydrochloride, dl
CCG-221017
Q-201098
CHEMBL3187408
mfcd00060167
sr-01000837506
SR-01000837506-2
CHEBI:31582
etilefrin, hydrochloride
AS-13925
etilefrine (hydrochloride)
3-(2-(ethylamino)-1-hydroxyethyl)phenol hydrochloride
Q27295283
D90499
benzenemethanol, a-[(ethylamino)methyl]-3-hydroxy-, hydrochloride
943-17-9 (hcl)
3-[2-(ethylamino)-1-hydroxyethyl]phenol;hydrochloride
CS-0030673
HY-A0144A

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index43.88 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index57.13 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (43.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]