Compounds > ethylenesulfonic acid
Page last updated: 2024-11-06

ethylenesulfonic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Ethylenesulfonic acid (ESA) is a colorless, hygroscopic, strong organic acid with the formula CH2(SO3H)CH2OH. It is a versatile chemical intermediate used in various applications, including the production of surfactants, resins, and polymers. ESA is typically synthesized by reacting ethylene oxide with sulfur trioxide in the presence of a catalyst. Its strong acidic nature makes it an effective catalyst in organic reactions, such as esterification and alkylation. ESA is also used as a plasticizer in the production of polymers, enhancing their flexibility and processability. The biological effects of ESA are not well-studied, but it is generally considered to be a relatively safe compound. ESA's importance stems from its wide range of applications in various industries, and its properties make it a valuable chemical intermediate. Research on ESA focuses on developing new synthetic methods, exploring its potential applications in various fields, and investigating its environmental impact.'

Cross-References

ID SourceID
PubMed CID62474
CHEMBL ID1236690
SCHEMBL ID16079
MeSH IDM0227449

Synonyms (31)

Synonym
V0134
CHEMBL1236690
1184-84-5
ethylenesulfonic acid
ethenesulfonic acid
nsc8957
VSO ,
vinylsulphonic acid
vinylsulfonic acid
1RQL ,
DB04359
AKOS006230508
unii-gj6489r1we
ethylenesulphonic acid
gj6489r1we ,
einecs 214-676-1
vsa-s
vsa-h
SCHEMBL16079
NLVXSWCKKBEXTG-UHFFFAOYSA-N
ethylene sulfonic acid
vinyl sulfonic acid
DTXSID2047018
vinylsulfonic acid, >/=97%
T71619
FT-0722512
sodium ethenesulfonate(25%nasalt)
Q2527228
mfcd09743544
ethylenesulfonicacid
BS-44145
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain B, Phosphonoacetaldehyde HydrolaseBacillus cereusKi1,790.00001,790.00001,790.00001,790.0000AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2004The Journal of biological chemistry, Mar-05, Volume: 279, Issue:10
X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis.
AID1811Experimentally measured binding affinity data derived from PDB2004The Journal of biological chemistry, Mar-05, Volume: 279, Issue:10
X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (6.25)18.7374
1990's1 (6.25)18.2507
2000's8 (50.00)29.6817
2010's6 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.48 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		210amino-acid anion
malonic acid
malonic acid : An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.. dicarboxylic acid : Any carboxylic acid containing two carboxy groups.		2.0710alpha,omega-dicarboxylic acidhuman metabolite
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		1.9810adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
aniline
[no description available]		2.0310anilines;
primary arylamine
ethylene
Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges		1.9210alkene;
gas molecular entity		plant hormone;
refrigerant
acrylamide
[no description available]		2.0810acrylamides;
N-acylammonia;
primary carboxamide		alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin
acrylic acid
acrylic acid: RN given refers to parent cpd. acrylic acid : A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.		2.0210alpha,beta-unsaturated monocarboxylic acidmetabolite
maleimide
[no description available]		2.1110dicarboximide;
maleimides		EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
hydroxyethyl methacrylate
hydroxyethyl methacrylate: many of cited refs are for gel which refers to polymeric form of above cpd: POLYHYDROXYETHYL METHACRYLATE. 2-hydroxyethyl methacrylate : An enoate ester that is the monomethacryloyl derivative of ethylene glycol.		2.0510enoate esterallergen;
polymerisation monomer
3-(trimethoxysilyl)propyl methacrylate
3-(trimethoxysilyl)propyl methacrylate: structure in first source		2.0210
calcium oxalate
Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.. calcium oxalate : The calcium salt of oxalic acid, which in excess in the urine may lead to formation of oxalate calculi (kidney stones).		2.0510organic calcium salt
2-acrylamido-2-methylpropanesulfonate
2-acrylamido-2-methylpropanesulfonate: for detection of alkaline phosphatase; RN given refers to parent cpd; do not confuse with AMPS cpd		2.0210organosulfonic acid
2-(n-morpholino)ethanesulfonic acid
2-(N-morpholino)ethanesulfonic acid: RN given refers to parent cpd. 2-(N-morpholino)ethanesulfonic acid : A Good's buffer substance, pKa = 6.15 at 20 degreeC.		1.9810MES;
organosulfonic acid;
zwitterion
peroxymonosulfate
peroxymonosulfate: oxidizing agent in prevention of tooth discoloration; RN given refers to ion(2-)		2.0710sulfur oxide;
sulfur oxoanion
mesna
Mesna: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.		2.1510organosulfonic acid
ConditionIndicatedRelationship StrengthStudiesTrials
Erythroblastosis Fetalis
[description not available]		01.9210
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0210