Compounds > ethylenediamine platinum(ii) malonate
Page last updated: 2024-12-10

ethylenediamine platinum(ii) malonate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID3035205
MeSH IDM0115452

Synonyms (20)

Synonym
ethylenediammineplatinum(ii) malonate
nsc 146068
(ethane-1,2-diamine-n,n')(malonato(2-)-o,o')platinum
malpen
einecs 255-484-8
platinum, (1,2-ethanediamine-kappan,kappan')(propanedioato(2-)-kappao1,kappao3)-, (sp-4-2)-
platinum, (1,2-ethanediamine-n,n')(propanedioato(2-)-o,o')-, (sp-4-2)-
platinum (ii), (ethylenediammine)malonato-
jm-40
ethylenediamine platinum(ii) malonate
unii-9bt36e343a
jm 40
malopen
9bt36e343a ,
(sp-4-2)-(1,2-ethanediamine-.kappa.n1,.kappa.n2)(propanedioato(2-)-.kappa.o1,.kappa.o3)platinum
malonatoethylenediamineplatinum(ii)
platinum, (1,2-ethanediamine-.kappa.n,.kappa.n')(propanedioato(2-)-.kappa.o1,.kappa.o3)-, (sp-4-2)-
platinum, (1,2-ethanediamine-.kappa.n1,.kappa.n2)(propanedioato(2-)-.kappa.o1,.kappa.o3)-, (sp-4-2)-
(ethane-1,2-diamine-n,n')[malonato(2-)-o,o']platinum
Q27895836

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Calculated pharmacokinetic parameters (peak concentrations, half-lives, areas under the curve) were compared with the corresponding values in patients at the maximal tolerated dose."( Comparative pharmacokinetics of cisplatin and three analogues in mice and humans.
Elferink, F; Klein, I; Pinedo, HM; van der Vijgh, WJ; van Hennik, MB; Vermorken, JB; Winograd, B, 1987)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		1.9610halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
malonic acid
malonic acid : An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.. dicarboxylic acid : Any carboxylic acid containing two carboxy groups.		1.9610alpha,omega-dicarboxylic acidhuman metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		1.9710isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
platinum
Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.		2.3720elemental platinum;
nickel group element atom;
platinum group metal atom
carboplatin
[no description available]		2.8840
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9710
Emesis
[description not available]		01.9710
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.		01.9710
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.		01.9710
Vomiting
The forcible expulsion of the contents of the STOMACH through the MOUTH.		01.9710
Benign Neoplasms
[description not available]		01.9610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		01.9610