Compounds > elenoside
Page last updated: 2024-11-12

elenoside

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Description

elenoside: a lignan from Justicia hyssopifolia; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10458570
CHEMBL ID478583
MeSH IDM0390299

Synonyms (4)

Synonym
elenoside
CHEMBL478583
131189-74-7
4-(1,3-benzodioxol-5-yl)-6-hydroxy-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3h-benzo[f][2]benzofuran-1-one

Research Excerpts

Overview

Elenoside is a cytotoxic arylnapthalene lignan (NSC 644013-W/1) derived from Justicia hyssopifolia. Elenoside has an action similar to that of purgative and prokinetics drugs.

ExcerptReferenceRelevance
"Elenoside is a cytotoxic arylnapthalene lignan (NSC 644013-W/1) derived from Justicia hyssopifolia (Family: Acanthaceae). "( Central nervous activity of elenoside.
Alonso, SJ; Jorge, E; Navarro, E; Pérez, C; Trujillo, J, 2004)		2.06
"Elenoside is a lignan with an action similar to that of purgative and prokinetics drugs. "( Elenoside increases intestinal motility.
Alonso, SJ; Jorge, E; Navarro, E; Navarro, R; Trujillo, J, 2006)		3.22
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (64)

Assay IDTitleYearJournalArticle
AID359441Growth inhibition of human UACC257 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359421Toxicity in Swiss albino mouse assessed as loss of spontaneous movement at 50 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359415Toxicity in Swiss albino mouse assessed as loss of sight after 30 mins by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359459Growth inhibition of human HCC2998 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359425Toxicity in Swiss albino mouse assessed as loss of muscle tone at 10 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359418Toxicity in Swiss albino mouse assessed as loss of spontaneous movement at 25 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359449Growth inhibition of human UO31 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359409Toxicity in Swiss albino mouse assessed as reduction in motor affective response by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359463Growth inhibition of human KM12 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359458Growth inhibition of human NCI-H522 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359469Toxicity in Swiss albino mouse assessed as reduction in twitches by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359445Growth inhibition of human SNB19 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359213Toxicity in Swiss albino mouse assessed as reduction in spontaneous activity after 60 mins by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359429Growth inhibition of human K562 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359456Growth inhibition of human NCI-H23 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359442Growth inhibition of human UACC257 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359450Growth inhibition of human UO31 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359422Toxicity in Swiss albino mouse assessed as loss of muscle tone at 50 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359444Growth inhibition of human SF268 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359447Growth inhibition of human SNB75 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359454Growth inhibition of human NCI-H226 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359470Toxicity in Swiss albino mouse assessed as reduction in convulsions by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359452Growth inhibition of human DMS273 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359439Growth inhibition of human SK-MEL-5 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359417Toxicity in Swiss albino mouse assessed as reduction in tremors by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359466Growth inhibition of human OVCAR-3 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359412Toxicity in Swiss albino mouse assessed as reduction in equilibrium after 180 mins by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359433Growth inhibition of human RPMI8226 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359431Growth inhibition of human MOLT4 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359465Growth inhibition of human OVCAR-3 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359424Toxicity in Swiss albino mouse assessed as loss of spontaneous movement at 10 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359448Growth inhibition of human SNB75 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359413Toxicity in Swiss albino mouse assessed as loss of righting reflex after 30 mins by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359416Toxicity in Swiss albino mouse assessed as death after 5 days assessed after 24 hrs post treatment by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359414Toxicity in Swiss albino mouse assessed as loss of hypotonic gait after 30 mins by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359471Toxicity in Swiss albino mouse assessed as involvement of autonomic nervous system2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359461Growth inhibition of human HCT116 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359462Growth inhibition of human HCT116 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359464Growth inhibition of human KM12 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359430Growth inhibition of human K562 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359457Growth inhibition of human NCI-H522 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359460Growth inhibition of human HCC2998 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359427Growth inhibition of human CCRF-CEM cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359419Toxicity in Swiss albino mouse assessed as loss of muscle tone at 25 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359410Toxicity in Swiss albino mouse assessed as reduction in sensory-motor response by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359436Growth inhibition of human M19-MEL cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359434Growth inhibition of human RPMI8226 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359428Growth inhibition of human CCRF-CEM cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359455Growth inhibition of human NCI-H23 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359451Growth inhibition of human DMS273 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359411Toxicity in Swiss albino mouse assessed as reduction in muscular tone after 180 mins by Irwin test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359443Growth inhibition of human SF268 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359432Growth inhibition of human MOLT4 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359420Toxicity in Swiss albino mouse assessed as loss of righting reflex at 25 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359438Growth inhibition of human SK-MEL-2 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359468Growth inhibition of human OVCAR4 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359453Growth inhibition of human NCI-H226 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359435Growth inhibition of human M19-MEL cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359440Growth inhibition of human SK-MEL-5 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359446Growth inhibition of human SNB19 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359423Toxicity in Swiss albino mouse assessed as loss of righting reflex at 50 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359467Growth inhibition of human OVCAR4 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359426Toxicity in Swiss albino mouse assessed as loss of righting reflex at 10 mg/kg, ip after 1 hr by Lim test2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
AID359437Growth inhibition of human SK-MEL-2 cells at 100 uM2001Journal of natural products, Jan, Volume: 64, Issue:1
General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		3.2760
codeine
[no description available]		2.0310morphinane alkaloid;
organic heteropentacyclic compound		antitussive;
drug allergen;
environmental contaminant;
opioid analgesic;
opioid receptor agonist;
prodrug;
xenobiotic
ConditionIndicatedRelationship StrengthStudiesTrials