Compounds > eleganolone
Page last updated: 2024-12-11

eleganolone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

eleganolone: diterpene ketols from Bifurcaria bifurcata; has antimicrobial activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6439034
CHEMBL ID444409
MeSH IDM0090349

Synonyms (9)

Synonym
2,6,10,14-hexadecatetraen-4-one, 16-hydroxy-2,6,10,14-tetramethyl-, (e,e,e)-
(e,e,e)-16-hydroxy-2,6,10,14-tetramethyl-2,6,10,14-hexadecatetraen-4-one
eleganolone
brn 1968009
CHEMBL444409
(6e,10e,14e)-16-hydroxy-2,6,10,14-tetramethylhexadeca-2,6,10,14-tetraen-4-one
67880-32-4
(6e,10e,14e)-16-hydroxy-2,6,10,14-tetramethyl-2,6,10,14-hexadecatetraen-4-one
DTXSID701139176
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID400370Relaxation activity in guinea pig ileum assessed as relaxation of KCl-induced muscle contractions1998Journal of natural products, Jan-23, Volume: 61, Issue:1
Studies on the Synthesis of Elegan-Type Linear Diterpenes: The Efficient Total Syntheses of Eleganolone, Eleganolone Acetate, Elegandiol, Eleganonal, and Epoxyeleganolone
AID400369Relaxation activity in guinea pig ileum assessed as relaxation of BaCl2-induced muscle contractions1998Journal of natural products, Jan-23, Volume: 61, Issue:1
Studies on the Synthesis of Elegan-Type Linear Diterpenes: The Efficient Total Syntheses of Eleganolone, Eleganolone Acetate, Elegandiol, Eleganonal, and Epoxyeleganolone
AID577981Antibiofilm activity in Pseudoalteromonas sp. D41 assessed as bacterial adhesion after 15 mins using DAPI staining by micro-plate fluorescence reader2011Bioorganic & medicinal chemistry letters, Mar-01, Volume: 21, Issue:5
Targeting bacterial biofilms: design of a terpenoid-like library as non-toxic anti-biofilm compounds.
AID400368Relaxation activity in guinea pig ileum assessed as inhibition of histamine-induced muscle contractions1998Journal of natural products, Jan-23, Volume: 61, Issue:1
Studies on the Synthesis of Elegan-Type Linear Diterpenes: The Efficient Total Syntheses of Eleganolone, Eleganolone Acetate, Elegandiol, Eleganonal, and Epoxyeleganolone
AID577980Antibiofilm activity in Pseudoalteromonas sp. D41 assessed as bacterial adhesion at 500 uM after 15 mins using DAPI staining by micro-plate fluorescence reader2011Bioorganic & medicinal chemistry letters, Mar-01, Volume: 21, Issue:5
Targeting bacterial biofilms: design of a terpenoid-like library as non-toxic anti-biofilm compounds.
AID400367Relaxation activity in guinea pig ileum assessed as inhibition of acetylcholine-induced muscle contractions1998Journal of natural products, Jan-23, Volume: 61, Issue:1
Studies on the Synthesis of Elegan-Type Linear Diterpenes: The Efficient Total Syntheses of Eleganolone, Eleganolone Acetate, Elegandiol, Eleganonal, and Epoxyeleganolone
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
ConditionIndicatedRelationship StrengthStudiesTrials
Idiopathic Parkinson Disease
[description not available]		02.6620
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)		02.6620
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.2110
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9810
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9810