Compounds > elaiomycin
Page last updated: 2024-11-12

elaiomycin

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Description

elaiomycin: naturally occurring azoxyalkene; RN given refers to cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID20054902
CHEMBL ID2152468
SCHEMBL ID16431330
MeSH IDM0062177

Synonyms (30)

Synonym
nsc-88205
elaiomycin
23315-05-1
d-threo-4-methoxy-3-(1-octenylazoxy)-2-butanol
2-butanol, 4-methoxy-3-(1-octenyl-onn-azoxy)-, (e,z)-(2s,3s)-
d-threo-methoxy-3-(1-octenyl-onn-azoxy)-2-butanol
hsdb 5122
(e,z)-(2s,3s)-4-methoxy-3-(1-octenyl-onn-azoxy)-2-butanol
(2s,3s)-4-methoxy-3-(1'-cis-octenyl-cis-azoxy)-2-butanol
2-butanol, 4-methoxy-3-(1-octenyl-onn-azoxy)-, d-threo-
2-butanol, 4-methoxy-1((n(e),1z)-1-octenyl-onn-azoxy)-, (2s,3s)-
nsc 88205
2-butanol, 4-methoxy-3-(1-octenyl-onn-azoxy)-, (s-(r*,r*-(e,z)))-
brn 2417343
ACON1_001844
NCGC00180084-01
unii-227v1pl5tf
227v1pl5tf ,
CHEMBL2152468
2-butanol, 4-methoxy-3-((1z)-2-((1z)-1-octen-1-yl)-2-oxidodiazenyl)-, (2s,3s)-
4-methoxy-3-(1-octenyl-onn-azoxy)-2-butanol, (e,z)-(2s,3s)-
elaiomycin [mi]
4-methoxy-3-(1'-cis-octenyl-cis-azoxy)-2-butanol, (2s,3s)-
2-butanol, 4-methoxy-3-((n(z),1z)-1-octenyl-onn-azoxy)-, (2s,3s)-
2-butanol, 4-methoxy-3-(1-octenyl-onn-azoxy)-, (s-(r*,r*- (e,z)))-
elaiomycin, (+)-
2-butanol, 4-methoxy-3-(1-octenyl-onn-azoxy)-, (s-(r*,r*-(z,z)))-
SCHEMBL16431330
Q15410947
DTXSID801028152
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID691996Antifungal activity against Penicillium notatum JP36 P1 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691981Cytotoxicity against human RXF 486L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691834Antifungal activity against Aspergillus fumigatus ATCC 46645 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691975Cytotoxicity against human MAXF 401NL cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691984Antiproliferative activity against human K562 cells2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691987Antibacterial activity against Staphylococcus aureus 511 B3 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691978Cytotoxicity against human PAXF 1657L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691988Antibacterial activity against Escherichia coli 458 B4 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691838Cytotoxicity against human GXF251L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691983Antiproliferative activity against HUVEC2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691994Antifungal activity against Sporidiobolus salmonicolor 549 H4 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691974Cytotoxicity against human LXFL 529L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691989Antibacterial activity against Pseudomonas aeruginosa SG 137 B7 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691985Cytotoxicity against human HeLa cells2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691982Cytotoxicity against human UXF 1138L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691836Antifungal activity against Aspergillus niger DSM 737 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691991Antibacterial activity against methicillin-resistant Staphylococcus aureus 134/93 R9 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691976Cytotoxicity against human MEXF 462NL cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691839Cytotoxicity against human LXFA 629L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691980Cytotoxicity against human PXF 1752L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691993Antibacterial activity against Mycobacterium vaccae 10670 M4 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691995Antifungal activity against Candida albicans H8 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691992Antibacterial activity against vancomycin-resistant Enterococcus faecalis 1528 R10 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691986Antibacterial activity against Bacillus subtilis 6633 B1 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691979Cytotoxicity against human PRXF 22Rv1 cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691835Antifungal activity against amphotericin-resistant Aspergillus terreus DSM 826 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691837Cytotoxicity against human CXF HT29 cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691990Antibacterial activity against Pseudomonas aeruginosa K 799/61 B9 assessed as zone of inhibition at 50 ug/disc after 24 hrs by agar diffusion assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
AID691977Cytotoxicity against human OVXF 899L cells by propidium iodide-based fluorescence assay2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (75.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.31 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.		6.9310L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
threonine
Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.		1.9510amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
alkenes
[no description available]		1.9510
azaserine
Azaserine: Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.. azaserine : A carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species.		6.9310carboxylic ester;
diazo compound;
L-serine derivative;
non-proteinogenic L-alpha-amino acid		antifungal agent;
antimetabolite;
antimicrobial agent;
antineoplastic agent;
glutamine antagonist;
immunosuppressive agent;
metabolite
griseoviridin
griseoviridin: produced by Streptomyces griseus		6.9310
etamycin
etamycin: antibiotic substance (macrolide lactone) produced by Streptomyces griseus & allied Streptomyces; active against gram-positive Mycobacterium tuberculosis & some fungi & other coccal infections; see also neoviridogriseins; structure		1.9310
ConditionIndicatedRelationship StrengthStudiesTrials