dolichol-d-glucosylmonophosphate profile

Dolichol-d-glucosylmonophosphate (Dol-Glc-P) is a crucial intermediate in the biosynthesis of N-linked glycans, complex sugar structures attached to proteins in the endoplasmic reticulum (ER). Its synthesis involves the transfer of glucose-1-phosphate from UDP-glucose to dolichol phosphate by the enzyme dolichol phosphate glucosyltransferase (DPGT). Dol-Glc-P then serves as a donor of glucose for the assembly of the oligosaccharide precursor, Glc3Man9GlcNAc2, which is further processed and transferred to nascent polypeptide chains in the ER lumen.

The importance of Dol-Glc-P lies in its role in the formation of N-linked glycans, which are essential for protein folding, stability, and trafficking. Mutations in the genes encoding DPGT or other enzymes involved in Dol-Glc-P synthesis can lead to defects in protein glycosylation and cause various diseases.

Research on Dol-Glc-P focuses on understanding its synthesis, regulation, and the role it plays in various cellular processes. Studies also investigate the involvement of Dol-Glc-P in disease pathogenesis and explore potential therapeutic strategies targeting this pathway.'

beta-D-glucose 1-phosphate : The beta-anomer of D-glucose 1-phosphate. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	122250
CHEMBL ID	67622
CHEBI ID	16218
SCHEMBL ID	361623
MeSH ID	M0043832

Synonym
55607-88-0
1-phospho-beta-d-glucopyranose
beta-d-glucopyranose 1-(dihydrogen phosphate)
CHEBI:16218 ,
[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl] dihydrogen phosphate
.alpha.-d-glucose, 1-phosphate
xgp ,
1-o-phosphono-beta-d-glucopyranose
beta-d-glucose 1-phosphate
C00663
NCI44138
dolichol-d-glucosylmonophosphate
NCISTRUC1_000461
NCISTRUC2_000464
CHEMBL67622
glucosylphosphodolichol
dol-p-glc
beta-d-glucopyranose, 1-ester with dolichol dihydrogen phosphate
dolichylglucose phosphate
glucosylphosphoryldolicholbeta-d-glucopyranose, 1-ester with dolichol dihydrogen phosphate
beta-glucose-1-phosphate
EPITOPE ID:145000
SCHEMBL361623
.beta.-glucose-1-phosphate
.beta.-d-glucopyranose, 1-(dihydrogen phosphate)
glucopyranose, 1-(dihydrogen phosphate), .beta.-d-
14048-34-1
.beta.-d-glucopyranosyl phosphate
X9QC3WD5G5 ,
1-o-phosphono-beta-d-glucose; 1-o-phosphono-d-glucose; 1-o-phosphono-glucose
unii-x9qc3wd5g5
beta-d-glucopyranose, 1-(dihydrogen phosphate)
glucopyranose, 1-(dihydrogen phosphate), beta-d-
beta-d-glucopyranosyl phosphate
Q27098590
DTXSID001343619

Class	Description
D-glucopyranose 1-phosphate	A D-glucose monophosphate in which the phosphate group is located at position 1.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID91439	Inhibitory activity against HIV-1 integrase at 1 mM	2000	Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11	Developing a dynamic pharmacophore model for HIV-1 integrase.
AID91440	Inhibitory activity against HIV-1 integrase at 200 uM	2000	Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11	Developing a dynamic pharmacophore model for HIV-1 integrase.
AID91575	Inhibitory activity against HIV-1 integrase at 25 uM; ND denotes No data	2000	Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11	Developing a dynamic pharmacophore model for HIV-1 integrase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	22 (62.86)	18.7374
1990's	7 (20.00)	18.2507
2000's	5 (14.29)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (2.86)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	35 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hypericin [no description available]	2	1
mitoxantrone Mitoxantrone: An anthracenedione-derived antineoplastic agent.. mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.	2	1	dihydroxyanthraquinone	analgesic; antineoplastic agent
1,2,5,8-tetrahydroxy anthraquinone 1,2,5,8-tetrahydroxy anthraquinone: structure in first source. quinalizarin : A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions.	2	1	tetrahydroxyanthraquinone	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
uridine diphosphate Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.	1.95	1	pyrimidine ribonucleoside 5'-diphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
galactose galactopyranose : The pyranose form of galactose.	1.97	1	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
asparagine Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). asparagine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group.	2.37	2	amino acid zwitterion; asparagine; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tetramethylsilane [no description available]	2	1	organosilicon compound	NMR chemical shift reference compound
uridine diphosphate glucose Uridine Diphosphate Glucose: A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.. UDP-alpha-D-glucose : The alpha-anomer of UDP-alpha-D-glucose. It is used in nucleotide sugars metabolism.	3.22	6	UDP-D-glucose	fundamental metabolite
uridine diphosphate n-acetylglucosamine Uridine Diphosphate N-Acetylglucosamine: Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.	2.36	2
2,2-bis(bromomethyl)-1,3-propanediol 2,2-bis(bromomethyl)-1,3-propanediol: structure given in first source	1.96	1	primary alcohol
mannose mannopyranose : The pyranose form of mannose.	3.07	5	D-aldohexose; D-mannose; mannopyranose	metabolite
pentaethylenehexamine [no description available]	2	1
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	2.36	2	N-acetyl-D-glucosamine	epitope
rhamnose [no description available]	1.97	1	L-rhamnose
ethionine L-ethionine : An S-ethylhomocysteine that has S-configuration at the chiral centre.	1.96	1	S-ethylhomocysteine	antimetabolite; carcinogenic agent
1-deoxynojirimycin 1-deoxy-nojirimycin: structure in first source. duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.	1.99	1	2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid	anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	1.97	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
imidazolidinyl urea imidazolidinyl urea: RN given refers to parent cpd	2	1	ureas	antimicrobial agent
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	2	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
1,3-bis(tris(hydroxymethyl)methylamino)propane bis-tris propane : A water-soluble buffer substance used for the preparation of the biochemical and biological buffer solutions; pKa = 6.8 at 20 degreeC.	2	1	hexol	buffer
hirudonine hirudonine: RN given refers to parent cpd; structure	2	1
isomaltose [no description available]	2	1	glycosylglucose	human metabolite; metabolite; mouse metabolite
glucosamine D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.	2.37	2	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite
ergosterol [no description available]	1.98	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
maltitol maltitol : An alpha-D-glucoside consisting of D-glucitol having an alpha-D-glucosyl residue attached at the 4-position. Used as a sugar substitute.	2	1	alpha-D-glucoside; glycosyl alditol	laxative; metabolite; sweetening agent
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	2	1	cinnamate ester; tannin	food component; plant metabolite
bilirubin [no description available]	1.97	1	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
myricetin [no description available]	2	1	7-hydroxyflavonol; hexahydroxyflavone	antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite
quercetagetin quercetagetin: structure given in first source; inhibits aldose reductase in rat lens. quercetagetin : A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.	2	1	flavonols; hexahydroxyflavone	antioxidant; antiviral agent; plant metabolite
rosmarinic acid rosmarinic acid: RN given refers to parent cpd; promote OT project. (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration.. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.	2	1	rosmarinic acid	geroprotector; plant metabolite
ellagic acid [no description available]	2	1	catechols; cyclic ketone; lactone; organic heterotetracyclic compound; polyphenol	antioxidant; EC 1.14.18.1 (tyrosinase) inhibitor; EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor; EC 2.4.1.1 (glycogen phosphorylase) inhibitor; EC 2.5.1.18 (glutathione transferase) inhibitor; EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor; EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor; EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; food additive; fungal metabolite; geroprotector; plant metabolite; skin lightening agent
5-azidouridine 5'-diphosphoglucose 5-azidouridine 5'-diphosphoglucose: structure given in first source	1.97	1
famotidine [no description available]	2	1	1,3-thiazoles; guanidines; sulfonamide	anti-ulcer drug; H2-receptor antagonist; P450 inhibitor
dolichol monophosphate mannose Dolichol Monophosphate Mannose: A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.	4.12	16
4,5-di-O-caffeoylquinic acid [no description available]	2	1	quinic acid
chlorhexidine Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.	2	1	biguanides; monochlorobenzenes	antibacterial agent; antiinfective agent
dolichol monophosphate [no description available]	2.41	2
glycolipids [no description available]	2	1
tsushimycin tsushimycin: from Streptomyces Z-237	1.96	1
dihydrofolate dihydrofolic acid : A folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.	2	1	dihydrofolic acids	Escherichia coli metabolite; mouse metabolite
guanosine diphosphate Guanosine Diphosphate: A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.	1.97	1	guanosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor
guanosine diphosphate mannose Guanosine Diphosphate Mannose: A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.. GDP-D-mannose : A GDP-mannose in which the mannose fragment has D-configuration.. GDP-alpha-D-mannose : The alpha-anomer of GDP-D-mannose.	2.88	4	GDP-D-mannose	Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite
viomycin [no description available]	2	1	heterodetic cyclic peptide; peptide antibiotic	antitubercular agent

Condition	Relationship Strength	Studies
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.95	1
Plasma Cell Tumor [description not available]	1.96	1
Plasmacytoma Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.	1.96	1

dolichol-d-glucosylmonophosphate

Description

Cross-References

Synonyms (36)

Drug Classes (1)

Bioassays (3)

Research

Studies (35)

Market Indicators

Research Demand Index: 10.44

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