Compounds > dolastatin 16
Page last updated: 2024-11-08

dolastatin 16

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dolastatin 16: from sea hare Dolabella auricularia; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID177386
CHEMBL ID450711
SCHEMBL ID2277080
MeSH IDM0281180

Synonyms (6)

Synonym
CHEMBL450711
dolastatin 16
192214-57-6
SCHEMBL2277080
(6s,12r,15r,18s,24s,31s)-13,24,27-trimethyl-3-(1-phenylpropan-2-yl)-12,15,28-tri(propan-2-yl)-16,25-dioxa-1,4,10,13,22,29-hexazatetracyclo[29.3.0.06,10.018,22]tetratriacontane-2,5,11,14,17,23,26,30-octone
DTXSID701046086

Research Excerpts

Overview

Dolastatin 16 is a cyclic depsipeptide isolated from the marine invertebrates and cyanobacterium Lyngbya majuscula. Its bioactivity has been a historical question.

ExcerptReferenceRelevance
"Dolastatin 16 is a cyclic depsipeptide isolated from the marine invertebrates and cyanobacterium Lyngbya majuscula, however, its bioactivity has been a historical question. "( Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening.
Deng, W; Han, BN; He, S; Liang, TT; Mu, FZ; Zhao, Q, 2018)		2.19
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID403914Growth inhibition of human SK-MEL-5 cells1997Journal of natural products, Aug, Volume: 60, Issue:8
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
AID403917Growth inhibition of human MDA-N cells1997Journal of natural products, Aug, Volume: 60, Issue:8
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
AID403913Growth inhibition of human SF295 cells1997Journal of natural products, Aug, Volume: 60, Issue:8
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
AID355910Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT method2003Journal of natural products, May, Volume: 66, Issue:5
Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.
AID355911Cytotoxicity against human KM20L2 cells after 48 hrs by MTT method2003Journal of natural products, May, Volume: 66, Issue:5
Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.
AID403915Growth inhibition of human MCF7 cells1997Journal of natural products, Aug, Volume: 60, Issue:8
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
AID403916Growth inhibition of human MDA-MB-435 cells1997Journal of natural products, Aug, Volume: 60, Issue:8
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
AID355912Cytotoxicity against human SF295 cells after 48 hrs by MTT method2003Journal of natural products, May, Volume: 66, Issue:5
Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.
AID599552Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam.
AID403911Growth inhibition of human NCI-H460 cells1997Journal of natural products, Aug, Volume: 60, Issue:8
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
AID355913Cytotoxicity against human SK-MEL-5 cells after 48 hrs by MTT method2003Journal of natural products, May, Volume: 66, Issue:5
Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.
AID599551Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam.
AID403912Growth inhibition of human KM20L2 cells1997Journal of natural products, Aug, Volume: 60, Issue:8
Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's8 (72.73)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.72 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
valine
Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.		2.0110L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0610taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
tacrolimus
Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.		2.1710macrolide lactambacterial metabolite;
immunosuppressive agent
2-methyl-6-nitrobenzoic anhydride
2-methyl-6-nitrobenzoic anhydride: structure in first source		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.420
Cancer of Cervix
[description not available]		02.0110
Cancer of Esophagus
[description not available]		02.0110
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.0110
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS.		02.0110
Breast Cancer
[description not available]		02.1510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1510