Compounds > docosyl-triethylenetetraminepentaacetic acid

Page last updated: 2024-12-07

docosyl-triethylenetetraminepentaacetic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

docosyl-triethylenetetraminepentaacetic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	132039
CHEMBL ID	273355
SCHEMBL ID	8954314
MeSH ID	M0206654

Synonyms (10)

Synonym
3,6,9,12,tetraazatetracosanoic acid, 3,6,9,12-tetrakis(carboxymethyl)-
docosyl-triethylenetetraminepentaacetic acid
3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12,tetraazatetracosanoic acid
137203-80-6
docosyltriethylenetetraminepentaacetic acid
c22tt
CHEMBL273355
2-[2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-dodecylamino]acetic acid
SCHEMBL8954314
DTXSID30160106

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
" The bioavailability of PACAs can be improved by the addition of differing lengths of alkyl side chains that alter amphipathic properties."	( Pharmacological properties of orally available, amphipathic polyaminocarboxylic acid chelators for actinide decorporation. Bowman, BM; Miller, SC; Wang, X, 2010)	0.36

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID189358	Reduction in carcass 241Am after daily feeding of 200 uM of the compound/kg of body weight to rats for 10 days	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID191543	Percent retention in rat visera was measured in situ using intestinal tied-loop technique	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID191412	Percent retention in rat liver was measured in situ using intestinal tied-loop technique	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID191410	Percent retention in rat gut section was measured in situ using intestinal tied-loop technique	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID189389	Reduction in whole body 241Am after daily feeding of 200 uM of the compound/kg of body weight to rats for 10 days	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID192032	Weight gain after daily feeding of 200 uM of the compound/kg of body weight to rats for 10 days	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID191413	Percent retention in rat lumen was measured in situ using intestinal tied-loop technique	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID189365	Reduction in liver 241Am after daily feeding of 200 uM of the compound/kg of body weight to rats for 10 days	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID191409	Percent retention in rat carcass was measured in situ using intestinal tied-loop technique	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID57489	In vitro elimination of Pu (given as citrate) from in vivo tagged canine liver cytosol after administration of the compound; value expressed as following filtrate to residue activity	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID189357	Reduction in both femora 241Am after daily feeding of 200 uM of the compound/kg of body weight to rats for 10 days	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
AID189366	Reduction in one kidney 241AM after daily feeding of 200 uM of the compound/kg of body weight to rats for 10 days	1992	Journal of medicinal chemistry, Jan, Volume: 35, Issue:1	Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (42.86)	18.2507
2000's	3 (42.86)	29.6817
2010's	1 (14.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.34 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.42 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.34)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	2.44	2	0	pentacarboxylic acid	copper chelator
trientine Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.. TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group.. 2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.	3.26	6	0	polyazaalkane; tetramine	copper chelator
plutonium Plutonium: A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, and atomic number 94. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.	2.92	4	0	actinoid atom; f-block element atom
americium Americium: A completely man-made radioactive actinide with atomic symbol Am, and atomic number 95. Its valence can range from +3 to +6. Because of its nonmagnetic ground state, it is an excellent superconductor. It is also used in bone mineral analysis and as a radiation source for radiotherapy.	2.71	3	0	actinoid atom; f-block element atom
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	3.26	6	0	benzenes; phenyl acetates

Condition	Indicated	Relationship Strength	Studies	Trials
Bone Loss, Perimenopausal [description not available]	0	2.44	2	0
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	0	2.03	1	0
Osteoporosis, Postmenopausal Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.	0	2.44	2	0