Compounds > dithiodibenzoic acid
Page last updated: 2024-12-05

dithiodibenzoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID8409
CHEMBL ID118378
SCHEMBL ID144989
MeSH IDM0539361

Synonyms (80)

Synonym
AC-16180
STK720147
2,2'-disulfanediyldibenzoic acid
BB 0221183
nsc-633230
nsc-5346
nsc5346
2,2'-dithiosalicylic acid
nsc 405662
benzoic acid, 2,2'-dithiodi-
ai3-15534
2,2'-dithiobis(benzoic acid)
bis(o-carboxyphenyl) disulfide
2,2'-dithiodibenzoesaeure [german]
einecs 204-352-8
brn 2221810
nsc 5346
2,2'-dithiodi(benzoic acid)
nsc 633230
nsc 213
diphenyl disulfide-2,2'-dicarboxylic acid
nsc-405662
nsc213
nsc-213
diphenyldisulfide-2,2'-dicarboxylic acid
bis(2-carboxyphenyl) disulfide
2,2'-dithiodibenzoic acid
119-80-2
2,2'-dithiobis[benzoic acid]
bis(o-carboxylphenyl) disulfide
benzoic acid,2'-dithiobis-
benzoic acid,2'-dithiodi-
benzoic acid, 2,2'-dithiobis-
nsc633230
2-[(2-carboxyphenyl)disulfanyl]benzoic acid
nsc405662
MLS001216615
smr000544079
2,2'-dithiodibenzoic acid, >=95.0% (nt)
CHEMBL118378
D1437
AKOS003244797
A804360
NCGC00246262-01
2,2'-dithio salicylic acid
BBL010520
2-carboxyphenyl disulfide
HMS2856N08
ec 204-352-8
2,2'-dithiodibenzoesaeure
4-10-00-00279 (beilstein handbook reference)
58mgb5279d ,
unii-58mgb5279d
FT-0609301
2,2-dithiosalicylic acid
dithiobisbenzoic acid
LBEMXJWGHIEXRA-UHFFFAOYSA-N
2,2'dithiosalicylic acid
2,2'-dithiobisbenzoic acid
dithiodibenzoic acid
SCHEMBL144989
2-((2-carboxyphenyl)disulfanyl)benzoic acid
benzoic acid, o,o'-dithiobis-
DTXSID1059498
STR02473
mfcd00002465
2,2'-dithiosalicylic acid, 96%
benzoic acid, dithiobis-
J-004201
F0001-0311
2,2'-dithiodibenzoic acid, 97%
SY002412
2,2 inverted exclamation mark -dithiodibenzoic acid
2,2 inverted exclamation marka-dithiodibenzoic acid
AMY22032
EN300-18529
Q27261609
P20505
2,2'-dithiodibenzoicacid
Z62436286
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
thioredoxin reductaseRattus norvegicus (Norway rat)Potency3.54810.100020.879379.4328AID588453
phosphopantetheinyl transferaseBacillus subtilisPotency15.84890.141337.9142100.0000AID1490
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency28.18380.035520.977089.1251AID504332
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency39.81070.354828.065989.1251AID504847
chromobox protein homolog 1Homo sapiens (human)Potency63.09570.006026.168889.1251AID540317
DNA polymerase betaHomo sapiens (human)Potency89.12510.022421.010289.1251AID485314
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency11.91730.168316.404067.0158AID720504
eyes absent homolog 2 isoform aHomo sapiens (human)Potency100.00001.199814.641950.1187AID488837
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency22.38720.050127.073689.1251AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID89655Compound was tested for inhibition of HIV-1 replication in human T-cell by using XTT assay; Moderately active1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID89802Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay.1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID82614Tested against zinc finger of the recombinant HIV-1 p7NC toluenesulfonamide) residue for fluorometric measurements1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID82613Tested against zinc finger of the recombinant HIV-1 p7NC protein by using Trp residue for fluorometric measurements1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID81947Inhibitory concentration required for 50% production of p24 production.1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID81607Tested for cytoprotection against production of HIV-1 p24.1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID81249Effective concentration required for 50% production of p24 production.1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID89804Inhibition of HIV-1 replication in human T-cell by using XTT assay.1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID89801Inhibition of HIV-1 replication in human T-cell by using XTT assay.1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.92 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index27.14 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
disulfiram
[no description available]		1.9910organic disulfide;
organosulfur acaricide		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor
thiram
Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.. thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.		1.9910organic disulfideantibacterial drug;
antifungal agrochemical;
antiseptic drug
bis(1-piperidylthiocarbonyl)disulfide
bis(1-piperidylthiocarbonyl)disulfide: indicator for analysis of copper; structure		1.9910
dibenzyl disulfide
dibenzyl disulfide: structure in first source. dibenzyl disulfide : An organic disulfide that results from the formal oxidative dimerisation of benzyl thiol.		1.9910organic aromatic compound;
organic disulfide		metabolite
dixanthogen
[no description available]		1.9910thiocarbonyl compound
2,2'-diaminodiphenyldisulfide
2,2'-diaminodiphenyldisulfide: resin hardener		1.9910
2,2'-dithiobis(5-nitropyridine)
2,2'-dithiobis(5-nitropyridine): structure		1.9910
2,2'-dipyridyl disulfide
2,2'-dipyridyl disulfide: disulfide is an important moiety in this cpd. aldrithiol : A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.		1.9910organic disulfide;
pyridines		oxidising agent
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510