Compounds > dispiro-1,2,4,5-tetroxane
Page last updated: 2024-11-12

dispiro-1,2,4,5-tetroxane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID10131306
CHEMBL ID278291
SCHEMBL ID13182615
MeSH IDM0384254

Synonyms (3)

Synonym
CHEMBL278291
wr-148999
SCHEMBL13182615
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID121153Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 80(mg/kg); Experiment II1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID340745Antimalarial activity against Plasmodium falciparum NF542007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
AID121139Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 320(mg/kg); Experiment I1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID528283Antimalarial activity against chloroquine-resistant Plasmodium falciparum K12010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.
AID121144Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 40(mg/kg); Experiment I1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID340743Antimalarial activity against Plasmodium falciparum K12007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
AID157867In vivo antimalarial activity against Plasmodium falciparum W-21992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID144637Evaluated for the neurotoxicity against NB2a Neuroblastoma cells.2000Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
AID121152Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 80(mg/kg); Experiment I1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID118077In vivo evaluation for antimalarial activity against Plasmodium berghei in terms of survival days when administered orally in mice (Mus musculus)1999Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
AID157866In vivo antimalarial activity against Plasmodium falciparum D61992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID224854Evaluated for the percentage of subcutaneously to Plasmodium berghei infected mice on days 3, 4, and 5 post infection.2000Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
AID224682Evaluated for the survival of the mice when 64 mg/kg/day was administered subcutaneously to Plasmodium berghei infected mice on days 3, 4, and 5 post infection; 1/8, 2/10, 1/16, 1/182000Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
AID151363Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D62000Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
AID152143In vitro antimalarial activity against Plasmodium falciparum D6 (Sierra Leone)2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.
AID158647In vitro antimalarial activity against drug-resistant Plasmodium berghei KBG173 1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID118078In vivo evaluation for antimalarial activity against Plasmodium berghei in terms of survival days when administered subcutaneously in mice (Mus musculus)1999Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
AID235117Resistance index is defined as the ratio of IC50 of Plasmodium falciparum(W-2) clone to IC50 of Plasmodium falciparum(D6) clone1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID158549In vitro antimalarial activity against drug-resistant Plasmodium falciparum NF541999Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
AID528284Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF542010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.
AID121141Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 320(mg/kg); Survival beyond 60 days is considered curative; Experiment II; Survival beyond 60 days is considered curative (C)1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID152144In vitro antimalarial activity against Plasmodium falciparum W2 (Indochina)2000Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.
AID121145Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 40(mg/kg); Experiment II1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID121146Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 640(mg/kg); Experiment I1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID121268Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 160 (mg/kg); Experiment I1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID110853In vivo evaluation for antimalarial activity against Plasmodium berghei in percentage when administered subcutaneously in mice (Mus musculus)1999Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
AID340746Antimalarial activity as reduced parasitaemia at day 3 against Plasmodium berghei infected MORO mice (Mus musculus) at 100 mg/kg peroral dose2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
AID121137Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 20(mg/kg); Experiment II1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID528285Antimalarial activity against Plasmodium berghei infected in NMRI mice (Mus musculus) assessed as reduction in parasitaemia at 100 mg/kg, perorally administered 1 day post-infection measured 3 day post-infection2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.
AID340744Antimalarial activity as reduced parasitaemia at day 3 against Plasmodium berghei infected MORO mice (Mus musculus) at 100 mg/kg subcutaneous dose2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
AID121136Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 20(mg/kg); Experiment I1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID121270Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 160 (mg/kg); Experiment II; active (A)1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
AID151365Antimalarial activity against chloroquine-resistant Plasmodium falciparum W22000Journal of medicinal chemistry, Jul-13, Volume: 43, Issue:14
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
AID110852In vivo evaluation for antimalarial activity against Plasmodium berghei in percentage when administered orally in mice (Mus musculus)1999Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
AID158548In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K11999Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
AID121148Mean survival time of the treated mice (Mus musculus) beyond that of the control animals against Plasmodium berghei at dose 640(mg/kg); Experiment II; Survival beyond 60 days is considered curative (C)1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.31 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
artemether
Artemether: An artemisinin derivative that is used in the treatment of MALARIA.. artemether : An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		210artemisinin derivative;
cyclic acetal;
organic peroxide;
semisynthetic derivative;
sesquiterpenoid		antimalarial
artemotil
artemotil: structure given in first source; RN given refers to cpd without isomeric designation		210artemisinin derivative
artenimol
artenimol: derivative of antimalarial drug artemisinin (quinghaosu)		210
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		02.420
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.420
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		0210