Disodium cantharidin is the disodium salt of cantharidin, a toxic compound produced by blister beetles. While cantharidin itself is known for its blistering properties and has been used historically in medicine, disodium cantharidin is a synthetic derivative with different characteristics and applications. Research on disodium cantharidin focuses on its potential as a therapeutic agent for various conditions, including cancer, inflammatory disorders, and viral infections. Its mechanism of action is believed to involve inhibiting certain enzymes and pathways involved in cell proliferation and inflammation. Studies exploring its efficacy and safety in these contexts are ongoing.'
disodium cantharidin: inhibits type 1 and type 2A protein phosphatase; cantharidine is the 2,3-dicarboxylic anhydride; RN given refers to di-Na salt [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 121474 |
| MeSH ID | M0088439 |
| Synonym |
|---|
| 7-oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, disodium salt, (exo,exo)- |
| cantharidin disodium |
| disodium cantharidate |
| disodium cantharidin |
| disodium (1r,2s,3r,4s)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate |
| unii-8oif7x5mk8 |
| 8oif7x5mk8 , |
| 1465-77-6 |
| disodium;(1r,2s,3r,4s)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate |
| Excerpt | Reference | Relevance |
|---|---|---|
| "To evaluate the efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions." | ( Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions. Song, J; Wang, LZ; Zhang, HJ, 2015) | 0.42 |
| " Injection into the thorax using mannatide combined with sodium cantharidate vitamin B6 was performed for 37 patients in the experimental group and mannatide combined with cisplatin for 32 patients in the control group." | ( Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions. Song, J; Wang, LZ; Zhang, HJ, 2015) | 0.42 |
| "Regimen of mannatide combined with sodium cantharidate vitamin B6 had better improvement in quality-of-life and symptom relief, with a lower side-effect incidence in treatment of malignant pleural effusions." | ( Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions. Song, J; Wang, LZ; Zhang, HJ, 2015) | 0.42 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.13) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (14.29%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (71.43%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||