Diphenic anhydride, also known as 1,1'-biphenyl-2,2'-dicarboxylic anhydride, is a white crystalline solid with a melting point of 220-222 °C. It is an important intermediate in the synthesis of various pharmaceuticals and other organic compounds. The compound is synthesized through the oxidation of phenanthrene or biphenyl using chromic acid. Diphenic anhydride is a key building block in the synthesis of various polymers, including polyimides, which find applications in high-performance materials due to their exceptional thermal and chemical stability. The compound is also used in the synthesis of several other biologically active compounds, including diphenic acid, a component of some anti-inflammatory drugs. Diphenic anhydride's versatility in organic synthesis, coupled with its potential for applications in various fields, makes it a subject of continued scientific research. It is studied for its potential role in developing novel materials with improved properties and for exploring its applications in pharmaceutical chemistry. '
diphenic anhydride: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 72794 |
| CHEMBL ID | 1897807 |
| SCHEMBL ID | 257 |
| MeSH ID | M0232173 |
| Synonym |
|---|
| AC-18960 |
| diphenic acid anhydride |
| 2,2'-biphenyl-dicarboxylic acid anhydride |
| nsc67689 |
| mls002693609 , |
| nsc-67689 |
| 2,2'-diphenyldicarboxylic anhydride |
| diphenic anhydride |
| nsc-116225 |
| 6050-13-1 |
| 2,2'-biphenyldicarboxylic anhydride |
| nsc116225 |
| dibenz[c,7-dione |
| diphenic anhydride, 98% |
| NCIOPEN2_003417 |
| 2,2'-bibenzoic anhydride |
| D0865 |
| smr001559556 |
| benzo[d][2]benzoxepine-5,7-dione |
| dibenz[c,e]oxepin-5,7-dione |
| dibenzo[c,e]oxepine-5,7-dione |
| A832754 |
| HMS3086K11 |
| AKOS005215992 |
| nsc 67689 |
| nsc 116225 |
| einecs 227-950-0 |
| dibenz(c,e)oxepin-5,7-dione |
| biphenyl-2,2'-dicarboxylic anhydride |
| STL146621 |
| FT-0609291 |
| BBL027491 |
| SCHEMBL257 |
| dibenzo[c,e]oxepin-5,7-dione |
| 2,2'-biphenyl dicarboxylic acid anhydride |
| DTXSID0064094 |
| 2,2'-diphenic anhydride |
| W-105250 |
| CHEMBL1897807 |
| F0001-1586 |
| mfcd00004993 |
| diphenic anhydride, tech grade |
| D89732 |
| 9-oxatricyclo[9.4.0.0(2),?]pentadeca-1(11),2(7),3,5,12,14-hexaene-8,10-dione |
| AS-57028 |
| 9-oxatricyclo[9.4.0.0,2,7]pentadeca-1(15),2,4,6,11,13-hexaene-8,10-dione |
| CS-0250434 |
| EN300-50856 |
| SY049302 |
| Z608059576 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (22.00) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||