Compounds > dimethoxyethyl phthalate
Page last updated: 2024-09-21

dimethoxyethyl phthalate

Cross-References

ID SourceID
PubMed CID8344
CHEMBL ID1302251
SCHEMBL ID186285
MeSH IDM0109900

Synonyms (67)

Synonym
117-82-8
dimethoxyethyl phthalate
wln: 1o2ovr bvo2o1
2-methoxyethyl phthalate
phthalic acid, di(methoxyethyl) ester
nsc2147
1, bis(2-methoxyethyl) ester
kesscoflex mcp
phthalic acid, bis(2-methoxyethyl) ester
methyl glycol phthalate
bis(methoxyethyl) phthalate
bis(2-methoxyethyl) phthalate
dimethylglycol phthalate
nsc-2147
dimethoxy ethyl phthalate
1,2-benzenedicarboxylic acid, bis(2-methoxyethyl) ester
di(2-methoxyethyl)phthalate
NCGC00090803-01
di-(2-methoxyethyl)ester kyseliny ftalove [czech]
dimethyl cellosolve phthalate
nsc 2147
ai3-01366 (usda)
einecs 204-212-6
di-(2-methoxyethyl) ester kyseliny ftalove [czech]
kodaflex dmep
ai3-01366
di(2-methoxyethyl) phthalate
hsdb 5016
methox
brn 2056929
di-(2-methoxyethyl)phthalate
bis(methylglycol) phthalate, technical, >=90% (gc)
bis(2-methoxyethyl) benzene-1,2-dicarboxylate
P0965
phthalic acid bis(2-methoxyethyl) ester
NCGC00090803-02
4-09-00-03241 (beilstein handbook reference)
di-(2-methoxyethyl) ester kyseliny ftalove
unii-68w8xuo221
1,2-benzenedicarboxylic acid, 1,2-bis(2-methoxyethyl) ester
68w8xuo221 ,
di-(2-methoxyethyl)ester kyseliny ftalove
dtxsid8025094 ,
dtxcid805094
tox21_303033
cas-117-82-8
NCGC00256966-01
tox21_201857
NCGC00259406-01
CHEMBL1302251
AKOS015888206
SCHEMBL186285
bis (methylglycol) phthalate
di(methoxyethyl)phthalate
phthalic acid, di(2-methoxyethyl)ester
HSUIVCLOAAJSRE-UHFFFAOYSA-N
reomol p
methoxy ethyl phthalate
benzenedicarboxylic acid, bis(2-methoxyethyl) ester
bis(methylglycol) phthalate
J-003671
bis(2-methoxyethyl)phthalate
mfcd00042842
bis(methylglycol) phthalate, analytical standard
phthalic acid, bis-methylglycol ester
phthalic acid bis(2-methoxyethyl)ester
Q15632774

Research Excerpts

Overview

ExcerptReference
"Dimethoxyethyl phthalate (DMEP) is an environmental endocrine disruptor. "( Cai, Y; Han, W; Liu, C; Liu, H; Zhu, S, 2021)

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.58490.003245.467312,589.2998AID2517
GLI family zinc finger 3Homo sapiens (human)Potency61.50380.000714.592883.7951AID1259369
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.19950.001318.074339.8107AID926; AID938
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency34.58610.001530.607315,848.9004AID1224841
pregnane X nuclear receptorHomo sapiens (human)Potency10.00000.005428.02631,258.9301AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.93930.000229.305416,493.5996AID743069; AID743075
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (60.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's1 (10.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
mono(2-ethyl-5-hydroxyhexyl) phthalate[no description available]medium10phthalic acid monoesterhuman urinary metabolite;
human xenobiotic metabolite
deoxyguanosine[no description available]medium10purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine[no description available]medium10guanosinesbiomarker
mono(2-methoxyethyl) phthalate[no description available]medium20
phenyl acetate[no description available]medium20benzenes;
phenyl acetates
methoxyacetic acid[no description available]medium20ether;
monocarboxylic acid		antineoplastic agent;
apoptosis inducer;
human xenobiotic metabolite;
mutagen
methyl cellosolve[no description available]medium20glycol etherprotic solvent;
solvent
epichlorohydrin[no description available]medium10epoxide;
organochlorine compound
alpha-chlorohydrin[no description available]medium10chloropropane-1,2-diol
methyl methanesulfonate[no description available]medium10methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
diethylhexyl phthalate[no description available]medium10diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Drug-Induced0low10
Abnormality, Heart0low10
Cancer of Liver0low10
Cancer of the Liver0low10
Cancer, Hepatocellular0low10
Congenital Heart Defect0low10
Congenital Heart Defects0low10
Congenital Heart Disease0low10
Congenital Limb Deformities0low10
Defects, Congenital Heart0low10
Drug-Induced Abnormalities0low10
Fetal Death0low10
Fetal Demise0low10
Fetal Mummification0low10
Heart Abnormalities0low10
Heart Defect, Congenital0low10
Heart Defects, Congenital0low10
Heart, Malformation Of0low10
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatocellular Cancer0low10
Hydronephrosis0low10
Inflammation0low10
Innate Inflammatory Response0low10
Limb Deformities, Congenital0low10
Liver Cancer0low10
Liver Neoplasms0low10
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
Pregnancy0low30

Research Highlights

Dosage (2)

ArticleYear
Evaluation of a testicular sperm head counting technique using rats exposed to dimethoxyethyl phthalate (DMEP), glycerol alpha-monochlorohydrin (GMCH), epichlorohydrin (ECH), formaldehyde (FA), or methyl methanesulphonate (MMS).
Archives of toxicology, Volume: 53, Issue: 1		1983
Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and methoxyacetic acid in the rat.
Teratology, Volume: 32, Issue: 1		1985
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]