Compounds > dimethoxyethyl phthalate
Page last updated: 2024-12-05

dimethoxyethyl phthalate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID8344
CHEMBL ID1302251
SCHEMBL ID186285
MeSH IDM0109900

Synonyms (67)

Synonym
117-82-8
dimethoxyethyl phthalate
wln: 1o2ovr bvo2o1
2-methoxyethyl phthalate
phthalic acid, di(methoxyethyl) ester
nsc2147
1, bis(2-methoxyethyl) ester
kesscoflex mcp
phthalic acid, bis(2-methoxyethyl) ester
methyl glycol phthalate
bis(methoxyethyl) phthalate
bis(2-methoxyethyl) phthalate
dimethylglycol phthalate
nsc-2147
dimethoxy ethyl phthalate
1,2-benzenedicarboxylic acid, bis(2-methoxyethyl) ester
di(2-methoxyethyl)phthalate
NCGC00090803-01
di-(2-methoxyethyl)ester kyseliny ftalove [czech]
dimethyl cellosolve phthalate
nsc 2147
ai3-01366 (usda)
einecs 204-212-6
di-(2-methoxyethyl) ester kyseliny ftalove [czech]
kodaflex dmep
ai3-01366
di(2-methoxyethyl) phthalate
hsdb 5016
methox
brn 2056929
di-(2-methoxyethyl)phthalate
bis(methylglycol) phthalate, technical, >=90% (gc)
bis(2-methoxyethyl) benzene-1,2-dicarboxylate
P0965
phthalic acid bis(2-methoxyethyl) ester
NCGC00090803-02
4-09-00-03241 (beilstein handbook reference)
di-(2-methoxyethyl) ester kyseliny ftalove
unii-68w8xuo221
1,2-benzenedicarboxylic acid, 1,2-bis(2-methoxyethyl) ester
68w8xuo221 ,
di-(2-methoxyethyl)ester kyseliny ftalove
dtxsid8025094 ,
dtxcid805094
tox21_303033
cas-117-82-8
NCGC00256966-01
tox21_201857
NCGC00259406-01
CHEMBL1302251
AKOS015888206
SCHEMBL186285
bis (methylglycol) phthalate
di(methoxyethyl)phthalate
phthalic acid, di(2-methoxyethyl)ester
HSUIVCLOAAJSRE-UHFFFAOYSA-N
reomol p
methoxy ethyl phthalate
benzenedicarboxylic acid, bis(2-methoxyethyl) ester
bis(methylglycol) phthalate
J-003671
bis(2-methoxyethyl)phthalate
mfcd00042842
bis(methylglycol) phthalate, analytical standard
phthalic acid, bis-methylglycol ester
phthalic acid bis(2-methoxyethyl)ester
Q15632774

Research Excerpts

Overview

Dimethoxyethyl phthalate (DMEP) is an environmental endocrine disruptor.

ExcerptReferenceRelevance
"Dimethoxyethyl phthalate (DMEP) is an environmental endocrine disruptor. "( DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells.
Cai, Y; Han, W; Liu, C; Liu, H; Zhu, S, 2021)		2.06

Dosage Studied

ExcerptRelevanceReference
" On an equimolar dosage basis, DMEP, 2-ME, and MAA were equally potent, which is consistent with the hypothesis."( Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and methoxyacetic acid in the rat.
Randall, JL; Ritter, EJ; Ritter, JM; Scott, WJ, 1985)		0.6
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.58490.003245.467312,589.2998AID2517
GLI family zinc finger 3Homo sapiens (human)Potency61.50380.000714.592883.7951AID1259369
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.19950.001318.074339.8107AID926; AID938
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency34.58610.001530.607315,848.9004AID1224841
pregnane X nuclear receptorHomo sapiens (human)Potency10.00000.005428.02631,258.9301AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.93930.000229.305416,493.5996AID743069; AID743075
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (60.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's1 (10.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.33 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formaldehyde
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy		6.9610aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
methyl methanesulfonate
[no description available]		1.9610methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
alpha-chlorohydrin
alpha-Chlorohydrin: A chlorinated PROPANEDIOL with antifertility activity in males used as a chemosterilant in rodents.. 3-chloropropane-1,2-diol : A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.		1.9610chloropropane-1,2-diol
epichlorohydrin
Epichlorohydrin: A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.. epichlorohydrin : An epoxide that is 1,2-epoxypropene in which one of the methyl hydrogens is substituted by chlorine.		6.9610epoxide;
organochlorine compound
methyl cellosolve
methyl cellosolve: widely used industrial solvent for resins, lacquers, dyes & inks; may cause anemia macrocytosis, appearance of young granulocytes in blood; RN given refers to parent cpd		2.3720glycol etherprotic solvent;
solvent
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.		1.9610diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
methoxyacetic acid
methoxyacetic acid: RN given refers to parent cpd. methoxyacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group.		2.3720ether;
monocarboxylic acid		antineoplastic agent;
apoptosis inducer;
human xenobiotic metabolite;
mutagen
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.3720benzenes;
phenyl acetates
mono(2-methoxyethyl) phthalate
mono(2-methoxyethyl) phthalate: metabolite of dimethoxyethyl phthalate		2.3720
mono(2-ethyl-5-hydroxyhexyl) phthalate
mono(2-ethyl-5-hydroxyhexyl) phthalate: a metabolite of bis(2-ethylhexyl) phthalate. mono(2-ethyl-5-hydroxyhexyl) phthalate : A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the primary hydroxy group of 2-ethylhexane-1,5-diol		3.0110phthalic acid monoesterhuman urinary metabolite;
human xenobiotic metabolite
deoxyguanosine
[no description available]		2.0310purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.		2.0310guanosinesbiomarker
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0310
Cancer of Liver
[description not available]		02.0310
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0310
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0310
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.6530
Fetal Death
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.		01.9610
Congenital Limb Deformities
[description not available]		01.9610
Abnormality, Heart
[description not available]		01.9610
Hydronephrosis
Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.		01.9610
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		01.9610
Heart Defects, Congenital
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.		01.9610