dihydrotestosterone glucuronide profile

dihydrotestosterone glucuronide: RN given refers to (5alpha,17beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5alpha-dihydrotestosterone 17-O-(beta-D-glucuronide) : A steroid glucosiduronic acid that is 5alpha-dihydrotestosterone having a single beta-D-glucuronic acid residue attached at position 17. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	44263365
CHEBI ID	89417
MeSH ID	M0114608

Synonym
stanolone glucuronate
5-alpha-dihydrotestosterone glucuronide
LMST05010041
42037-24-1
2vvb2958e5 ,
dihydrotestosterone glucuronide
dihydrotestosterone 17-glucuronide
5alpha-dihydrotestosterone glucuronide
stanolone 17-glucuronide
5alpha-dihydrotestosterone-17g
5alpha-dihydrotestosterone 17-o-(beta-d-glucuronide)
17beta-hydroxy-5alpha-androstan-3-one glucuronide
5alpha-dihydrotestosterone 17-beta-glucuronide
5alpha-dihydrotestosterone 17-o-(beta-d-glucuronic acid)
CHEBI:89417
(5alpha,17beta)-3-oxoandrostan-17-yl beta-d-glucopyranosiduronic acid
5alpha-dihydrotestosterone 17-(beta-d-glucuronide)
3-oxo-5alpha-androstan-17beta-yl beta-d-glucopyranosiduronic acid
5-a-dihydrotestosterone glucuronide
5-alpha-androstan-17-beta-ol-3-one glucosiduronate
Q27161610
5.alpha.-dihydrotestosterone-o-glucuronide
.beta.-d-glucopyranosiduronic acid, (5.alpha.,17.beta.)-3-oxoandrostan-17-yl
5.alpha.-dihydrotestosterone glucuronide
17.beta.-hydroxy-5.alpha.-androstan-3-one glucuronide
DTXSID801305053
(2s,3s,4s,5r,6r)-6-[[(5s,8r,9s,10s,13s,14s,17s)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid

Role	Description
human urinary metabolite	Any metabolite (endogenous or exogenous) found in human urine samples.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
steroid glucosiduronic acid
3-oxo-5alpha-steroid	A 3-oxo steroid that has alpha configuration at position 5.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Biochemical pathways: part I	0	466

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (36.36)	18.7374
1990's	4 (36.36)	18.2507
2000's	2 (18.18)	29.6817
2010's	1 (9.09)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
estriol hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone. chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.	1.96	1	16alpha-hydroxy steroid; 17beta-hydroxy steroid; 3-hydroxy steroid	estrogen; human metabolite; human xenobiotic metabolite; mouse metabolite
androsterone [no description available]	1.98	1	17-oxo steroid; 3alpha-hydroxy steroid; androstanoid; C19-steroid	androgen; anticonvulsant; human blood serum metabolite; human metabolite; human urinary metabolite; mouse metabolite; pheromone
ethinyl estradiol Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.. 17alpha-ethynylestradiol : A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.	1.96	1	17-hydroxy steroid; 3-hydroxy steroid; terminal acetylenic compound	xenoestrogen
taurocholic acid Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.. taurocholate : An organosulfonate oxoanion that is the conjugate base of taurocholic acid.. taurocholic acid : A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.	1.96	1	amino sulfonic acid; bile acid taurine conjugate	human metabolite
lithocholic acid Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.. lithocholic acid : A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.. lithocholate : A bile acid anion that is the conjugate base of lithocholic acid.	1.97	1	bile acid; C24-steroid; monohydroxy-5beta-cholanic acid	geroprotector; human metabolite; mouse metabolite
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	3.78	11	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
androstane-3,17-diol Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.	2.67	3	17-hydroxy steroid; 3-hydroxy steroid; androstanoid
testosterone undecanoate [no description available]	1.98	1	steroid ester
testosterone 17-glucosiduronate testosterone glucuronate: natural conjugate isolated from human plasma; RN given refers to (beta)-isomer. testosterone 17-glucosiduronic acid : A steroid glucosiduronic that is testosterone carrying a glucosiduronic acid residue at position 17.	2.21	1	3-oxo steroid; beta-D-glucosiduronic acid; enone; steroid glucosiduronic acid	human metabolite
androsterone glucuronide androsterone glucuronide: RN given refers to (3alpha,5alpha)-isomer. androsterone 3-glucosiduronic acid : A steroid glucosiduronic acid having androsterone as the steroid component.	1.98	1	beta-D-glucosiduronic acid; steroid glucosiduronic acid	human metabolite; metabolite; mouse metabolite
estriol glucuronide [no description available]	1.96	1
androstane-3,17-diol glucuronide androstane-3,17-diol glucuronide: RN given refers to cpd with unspecified glucuronide locant	2.67	3	steroid ester
ethinyl estradiol glucuronide [no description available]	1.96	1

Condition	Relationship Strength	Studies
Adenoma, Prostatic [description not available]	2.01	1
Prostatic Hyperplasia Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.	2.01	1
Bile Duct Obstruction [description not available]	1.96	1
Cholestasis Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).	1.96	1
Adenocarcinoma, Basal Cell [description not available]	1.99	1
Cancer of Prostate [description not available]	2.4	2
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.99	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.4	2
Hormone-Dependent Neoplasms [description not available]	1.99	1
Congenital Adrenal Hyperplasia [description not available]	1.98	1
Adrenal Hyperplasia, Congenital A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.	1.98	1
Menopause The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.	1.98	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.97	1
Hirsutism A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.	1.97	1
Polycystic Ovarian Syndrome [description not available]	1.97	1
Polycystic Ovary Syndrome A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.	1.97	1
Thyroid Diseases Pathological processes involving the THYROID GLAND.	1.97	1

dihydrotestosterone glucuronide

Description

Cross-References

Synonyms (27)

Roles (1)

Drug Classes (2)

Pathways (1)

Research

Studies (11)

Market Indicators

Research Demand Index: 11.78

Study Types