Compounds > dihydrophylloquinone

Page last updated: 2024-12-08

dihydrophylloquinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	152059
CHEMBL ID	2068846
SCHEMBL ID	571584
MeSH ID	M0333910

Synonyms (17)

Synonym
2-methyl-3-(3,7,11,15-tetramethylhexadecyl)-1,4-naphthalenedione
2-methyl-3-(3,7,11,15-tetramethylhexadecyl)naphthalene-1,4-dione
FT-0667168
1,4-naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethylhexadecyl)-
64236-23-3
SCHEMBL571584
CHEMBL2068846
2-methyl-3-(3,7,11,15-tetramethylhexadecyl)-1,4-dihydronaphthalene-1,4-dione
2',3'-dihydro-phytomenadione
AKOS030254620
2',3'-dihydrovitamin k1
2-methyl-3-(3,7,11,15-tetramethylhexadecyl)-1,4-naphthalenedione, 9ci
dihydrophylloquinone
DTXSID10982782
beta,gamma-dihydro vitamin k1
?,?-dihydro vitamin k1
beta , gamma -dihydrovitamin k1

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
" In rats, dihydro-K1 is well absorbed and detected in the tissues of the brain, pancreas, kidney, testis, abdominal aorta, liver and femur."	( The biological activity and tissue distribution of 2',3'-dihydrophylloquinone in rats. Hara, Y; Harada, H; Isobe, Y; Kamo, S; Konishi, S; Ozaki, R; Saitoh, S; Sato, T, 2003)	0.56

Dosage Studied

Excerpt	Relevance	Reference
"816), were found to be inversely associated with the risk of pancreatic cancer in a nonlinear dose-response manner (all P values for nonlinearity < 0."	( Dietary Vitamin K Intake and the Risk of Pancreatic Cancer: A Prospective Study of 101,695 American Adults. Cheng, L; Gong, JP; Hu, JJ; Li, QJ; Peng, Y; Sun, WP; Wu, JJ; Yang, PF; Yu, DW; Zhong, GC, 2021)	0.62

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (10.00)	18.2507
2000's	6 (60.00)	29.6817
2010's	2 (20.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	26.04 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	5.27 (4.65)
Search Engine Demand Index	26.67 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (26.04)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (20.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
vitamin k 3 Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.	2.03	1	0	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical
vitamin k semiquinone radical vitamin K semiquinone radical: found in active preparations of vitamin K-dependent carboxylase. vitamin K : Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.	4.12	3	1
vitamin k1 hydroquinone vitamin K1 hydroquinone: metabolite of vitamin K1 & vitamin K1 2,3-epoxide	2.01	1	0	naphthohydroquinone; polyprenylhydroquinone
menatetrenone menaquinone-4 : A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration.	2.44	2	0	menaquinone	anti-inflammatory agent; antioxidant; bone density conservation agent; human metabolite; neuroprotective agent
menaquinone 6 menaquinone 6: RN given refers to (all-E)-isomer	2.77	3	0
vitamin k 1 Vitamin K 1: A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.. phylloquinone : A member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones.	6.6	10	2	phylloquinones; vitamin K	cofactor; human metabolite; plant metabolite
menaquinone 7 menaquinone-7 : A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation.	2.03	1	0	menaquinone	bone density conservation agent; cofactor; Escherichia coli metabolite; human blood serum metabolite; Mycoplasma genitalium metabolite
i(3)so3-galactosylceramide Sulfoglycosphingolipids: GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups.. 1-(3-O-sulfo-beta-D-galactosyl)-N-tetracosanoylsphingosine : A D-galactosyl-N-acylsphingosine having a sulfo group at the 3-position on the galactose ring and tetracosanoyl as the N-acyl group.	2.05	1	0	galactosylceramide sulfate; N-acyl-beta-D-galactosylsphingosine

Condition	Indicated	Relationship Strength	Studies	Trials
Cancer of Pancreas [description not available]	0	2.31	1	0
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	0	2.31	1	0
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	0	2.02	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	0	2	1	0
Bone Fractures [description not available]	0	4.31	1	1
Bone Loss, Osteoclastic [description not available]	0	4.31	1	1
Fractures, Bone Breaks in bones.	0	4.31	1	1