Diethyl aminomalonate is a versatile building block in organic synthesis, particularly for the preparation of α-amino acids. It is a white crystalline solid that is commonly used as a starting material in the Strecker synthesis, a classic method for synthesizing α-amino acids. The compound is also used in the synthesis of pharmaceuticals and agrochemicals. Diethyl aminomalonate is readily available commercially and can be synthesized through a variety of methods, including the reaction of diethyl malonate with ammonia. Due to its importance in synthetic chemistry, diethyl aminomalonate has been extensively studied, with researchers exploring its reactivity and applications in various chemical reactions. '
diethyl aminomalonate: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 81272 |
| CHEBI ID | 165846 |
| SCHEMBL ID | 338079 |
| MeSH ID | M0160195 |
| Synonym |
|---|
| 1,3-diethyl 2-aminopropanedioate |
| EN300-24015 |
| nsc 121992 |
| propanedioic acid, amino-, diethyl ester |
| einecs 229-905-0 |
| nsc-121992 |
| 6829-40-9 |
| nsc121992 |
| diethyl aminomalonate |
| CHEBI:165846 |
| diethyl 2-aminopropanedioate |
| diethyl 2-aminomalonate |
| 2-aminomalonic acid diethyl ester |
| AKOS009086612 |
| FT-0601119 |
| SCHEMBL338079 |
| AB00443476-03 |
| diethyl 2-aminomalonate # |
| W-104681 |
| F8889-7946 |
| CCG-245161 |
| diethyl 2-aminomalonate, aldrichcpr |
| NCGC00335393-01 |
| aminomalonic acid diethyl ester |
| CS-0113084 |
| diethyl2-aminomalonate |
| DTXSID30987815 |
| diethyl aminopropanedioate |
| 2-amino-malonic acid diethyl ester |
| Class | Description |
|---|---|
| alpha-amino acid ester | The amino acid ester derivative obtained the formal condensation of an alpha-amino acid with an alcohol. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (51.55) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||