dichloroacetylene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	24227
CHEBI ID	4503
MeSH ID	M0043855

Synonyms (20)

Synonym
ethyne, dichloro-
acetylene, dichloro-
dichloroethyne
hsdb 7200
ccris 5411
dichloroacetylene [forbidden]
7572-29-4
dichloroacetylene
1,2-dichloroethyne
1,2-dichloro-ethyne
95i833jv4s ,
unii-95i833jv4s
dichloroacetylene [hsdb]
dichloroacetylene [iarc]
CHEBI:4503
clc.$.ccl
1,2-dichloroacetylene #
c2cl2
DTXSID7020429
Q20963653

Research Excerpts

Overview

Dichloroacetylene (DCA) is a highly reactive compound that decomposes rapidly in contact with air. It is a potent nephrotoxin and nephrocarcinogen in rodents.

Excerpt	Reference	Relevance
"Dichloroacetylene (DCA) is a highly reactive compound that decomposes rapidly in contact with air into a series of chlorinated aliphatic hydrocarbons (e.g., phosgene, trichloroacetyl chloride, trichloroacryloyl chloride and hexachlorobutadiene). "	( Mutagenicity of dichloroacetylene and its degradation products trichloroacetyl chloride, trichloroacryloyl chloride and hexachlorobutadiene. Henschler, D; Neudecker, T; Reichert, D; Spengler, U, 1983)	2.05
"Dichloroacetylene (DCA) is a by-product of the synthesis of certain chlorinated, aliphatic hydrocarbons (e.g., vinylidene chloride). "	( Carcinogenicity of dichloroacetylene: an inhalation study. Henschler, D; Reichert, D; Romen, W; Spengler, U, 1984)	2.04
"Dichloroacetylene (DCA) is a potent nephrotoxin and nephrocarcinogen in rodents. "	( Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation. Dekant, W; Henschler, D; Kanhai, W, )	1.86

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
organochlorine compound	An organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (41.18)	18.7374
1990's	6 (35.29)	18.2507
2000's	3 (17.65)	29.6817
2010's	1 (5.88)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.97

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	26.97 (24.57)
Research Supply Index	3.04 (2.92)
Research Growth Index	4.22 (4.65)
Search Engine Demand Index	31.58 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (26.97)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.00%)	6.00%
Case Studies	1 (5.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.01	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.	1.98	1	nitrosamine	geroprotector; mutagen
acetylene [no description available]	5.27	17	alkyne; gas molecular entity; terminal acetylenic compound
trichloroacetyl chloride [no description available]	6.96	1
trichloroacetic acid Trichloroacetic Acid: A strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts.. trichloroacetic acid : A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.	1.96	1	monocarboxylic acid; organochlorine compound	carcinogenic agent; metabolite; mouse metabolite
trichloroethylene Trichloroethylene: A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.. triol : A chemical compound containing three hydroxy groups.	3.08	5	chloroethenes	inhalation anaesthetic; mouse metabolite
taurocholic acid Taurocholic Acid: The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.. taurocholate : An organosulfonate oxoanion that is the conjugate base of taurocholic acid.. taurocholic acid : A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.	2.02	1	amino sulfonic acid; bile acid taurine conjugate	human metabolite
hexachlorobutadiene hexachlorobutadiene: a potent nephrotoxicant in rats; structure	6.96	1	organochlorine compound
hexachlorobenzene Hexachlorobenzene: An agricultural fungicide and seed treatment agent.. hexachlorobenzene : A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.	2	1	aromatic fungicide; chlorobenzenes	antifungal agrochemical; carcinogenic agent; persistent organic pollutant
nitrilotriacetic acid Nitrilotriacetic Acid: A derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.)	1.98	1	NTA; tricarboxylic acid	carcinogenic agent; nephrotoxic agent
methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.	1.98	1	N-nitrosoureas	alkylating agent; carcinogenic agent; mutagen; teratogenic agent
cupric chloride cupric chloride: RN given refers to unlabeled parent cpd. copper(II) chloride : An inorganic chloride of copper in which the metal is in the +2 oxidation state.	2	1	copper molecular entity; inorganic chloride	EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor
ferric nitrilotriacetate ferric nitrilotriacetate: induces diabetes in animals (iron loading)	1.98	1	iron chelate	carcinogenic agent; mutagen
tetrachloroethylene Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.	2.01	1	chlorocarbon; chloroethenes	nephrotoxic agent
bromates Bromates: Negative ions or salts derived from bromic acid, HBrO3.	1.98	1	bromine oxoanion; monovalent inorganic anion
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	7.01	1	cobalt group element atom; metal allergen	micronutrient
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2	1
myelin basic protein Myelin Basic Protein: An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.	1.98	1
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	6.98	1	cysteinium	fundamental metabolite
s-(1,2-dichlorovinyl)cysteine S-(1,2-dichlorovinyl)cysteine: RN given refers to (L-Cys)-isomer; structure given in first source. S-(cis-1,2-dichlorovinyl)-L-cysteine : An S-(1,2-dichlorovinyl)-L-cysteine in which the dichlorovinyl group has cis- (Z-) geometry.	1.98	1	S-(1,2-dichlorovinyl)-L-cysteine
s-(1,2-dichlorovinyl)glutathione [no description available]	6.98	1	peptide
potassium bromate potassium bromate: used as bread improver	1.98	1	bromate salt; potassium salt	flour treatment agent
phenolphthalein glucuronide phenolphthalein glucuronide: RN given refers to parent cpd	2.02	1
vitamin b 12 Vitamin B 12: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.	2.01	1

Condition	Relationship Strength	Studies
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.37	2
Cancer of Eye [description not available]	1.96	1
Cancer of Kidney [description not available]	1.96	1
Experimental Neoplasms [description not available]	3.3	2
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.96	1
Acute Liver Injury, Drug-Induced [description not available]	1.95	1
Acute Kidney Tubular Necrosis [description not available]	1.95	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	1.95	1
Kidney Tubular Necrosis, Acute Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.	1.95	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	1.95	1
Nerve Degeneration Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.	1.95	1

chemdatabank.com