Compounds > desmethylenylnocardamine
Page last updated: 2024-08-03 01:11:56

desmethylenylnocardamine

Description

desmethylenylnocardamine: cyclic peptide of the nocardamine class from a marine-derived bacterium of the genus Streptomyces; structure in first source [MeSH]

1,11,22-Trihydroxy-1,6,11,16,22,27-hexazacyclodotriacontane-2,5,12,15,23,26-hexone : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID14671620
CHEMBL ID517615
CHEBI ID181598
MeSH IDM0485823

Synonyms (21)

Synonym
CHEBI:181598
1,11,22-trihydroxy-1,6,11,16,22,27-hexazacyclodotriacontane-2,5,12,15,23,26-hexone
ACON0_001492
NCGC00180613-01
ACON1_001337
MLS000863563 ,
smr000440712
MEGXM0_000271
desmethylenylnocardamine
CHEMBL517615
HMS2269F05
1,11,22-trihydroxy-1,6,11,16,22,27-hexazacyclodotriacontane-2,5,12,15,23,26-triquinone
1,11,22-tris(oxidanyl)-1,6,11,16,22,27-hexazacyclodotriacontane-2,5,12,15,23,26-hexone
cid_14671620
bdbm77562
desferrioxamine d2
proferrioxamine-d2, >=95% (lc/ms-elsd)
126988-91-8
DTXSID001347778
proferrioxamine-d2
AKOS040736064

Drug Classes (2)

ClassDescription
keratan 6'-sulfateA keratan sulfate with random sulfation at the 6'-position.
azamacrocycleA cyclic macromolecule containing one or more nitrogen atoms in place of carbon either as the divalent group NH for the group CH2 or a single trivalent nitrogen atom for the group CH.

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency4.4668AID2147
phosphopantetheinyl transferaseBacillus subtilisPotency89.1251AID1490
TDP1 proteinHomo sapiens (human)Potency26.1011AID686978; AID686979
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency7.9433AID720542
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency56.2341AID504333
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency50.1187AID2100
gemininHomo sapiens (human)Potency1.6360AID624296
Guanine nucleotide-binding protein GHomo sapiens (human)Potency3.9811AID624287

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
exodeoxyribonuclease V subunit RecDEscherichia coli str. K-12 substr. MG1655IC50118.5490AID492957
exodeoxyribonuclease V subunit RecBEscherichia coli str. K-12 substr. MG1655IC50118.5490AID492957
exodeoxyribonuclease V subunit RecCEscherichia coli str. K-12 substr. MG1655IC50118.5490AID492957

Bioassays (18)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID401622Antibacterial activity against Salmonella Typhimurium ATCC 14028 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401624Antifungal activity against Trichophyton mentagrophytes IFO 40996 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401619Antibacterial activity against Staphylococcus aureus ATCC 6538 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401625Antifungal activity against Trichophyton rubrum IFO 6204 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401623Antifungal activity against Candida albicans ATCC 10231 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401621Antibacterial activity against Klebsiella pneumoniae ATCC 10031 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401626Antimycobacterial activity against Proteus vulgaris ATCC 3851 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401618Antibacterial activity against Micrococcus luteus ATCC 10240 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401627Inhibition of Staphylococcus aureus sortase B2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401620Antibacterial activity against Escherichia coli ATCC 11775 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.
AID401617Antibacterial activity against Bacillus subtilis ATCC 6633 at 200 ug/mL2005Journal of natural products, Apr, Volume: 68, Issue:4
ISSN: 0163-3864		Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces.

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
laurolactam
0
azamacrocycle;
keratan 6'-sulfate		00low000000
bisucaberin
0
azamacrocycle;
keratan 6'-sulfate		00low000000
cyclomarin a
0
azamacrocycle;
keratan 6'-sulfate		00low000000
plerixafor
0
azacycloalkane;
azamacrocycle;
benzenes;
crown amine;
secondary amino compound;
tertiary amino compound		anti-HIV agent;
antineoplastic agent;
C-X-C chemokine receptor type 4 antagonist;
immunological adjuvant		00low000000
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
0
azamacrocyclechelator;
copper chelator		00low000000
anidulafungin
0
antibiotic antifungal drug;
azamacrocycle;
echinocandin;
heterodetic cyclic peptide;
semisynthetic derivative		00low000000
palustrine
0
azamacrocycle;
lactam		00low000000
thiocillin
0
azamacrocycle;
lactam		00low000000
mycotrienin i
0
azamacrocycle;
lactam		00low000000
vicenistatin
0
azamacrocycle;
lactam		00low000000
ym 216391
0
1,3-oxazoles;
1,3-thiazoles;
azamacrocycle;
benzenes;
heterodetic cyclic peptide		antineoplastic agent;
bacterial metabolite		00low000000
mk-7009
0
azamacrocycle;
carbamate ester;
cyclopropanes;
N-sulfonylcarboxamide;
pyrrolidinecarboxamide		antiviral drug;
hepatitis C protease inhibitor		00low000000
simeprevir
0
azamacrocycle;
lactam		00low000000
grazoprevir
0
aromatic ether;
azamacrocycle;
carbamate ester;
cyclopropanes;
lactam;
N-sulfonylcarboxamide;
quinoxaline derivative		antiviral drug;
hepatitis C protease inhibitor;
hepatoprotective agent		00low000000
N-[(4-chlorophenyl)methyl]-2-[(2R,6S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
0
azamacrocycle;
lactam		00low000000
pf-06463922
0
aminopyridine;
aromatic ether;
azamacrocycle;
benzamides;
cyclic ether;
monofluorobenzenes;
nitrile;
organic heterotetracyclic compound;
pyrazoles		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor		00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
deferrioxamine e
1
cyclic desferrioxamine;
cyclic hydroxamic acid;
macrocycle		antineoplastic agent;
bacterial metabolite;
marine metabolite;
siderophore		2005200519.0high000100
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
deferrioxamine e
1
cyclic desferrioxamine;
cyclic hydroxamic acid;
macrocycle		antineoplastic agent;
bacterial metabolite;
marine metabolite;
siderophore		2005200519.0high000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100