Compounds > desbromoarborescidine a
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desbromoarborescidine a

Description

desbromoarborescidine A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11276206
CHEMBL ID93136
MeSH IDM0492850

Synonyms (5)

Synonym
desbromoarborescidine a
CHEMBL93136
10252-12-7
(12bs)-1,2,3,4,6,7,12,12bbeta-octahydroindolo[2,3-a]quinolizine
(12bs)-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID5796Binding affinity analysed for 5-HT 2B receptor in rat stomach fundus1996Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14
Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.
AID432107Cytotoxicity against human KB cells at 30 uM2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Antiproliferative activity of arborescidine alkaloids and derivatives.
AID432106Cytotoxicity against human HL60 cells after 3 days by MTT assay2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Antiproliferative activity of arborescidine alkaloids and derivatives.
AID432105Cytotoxicity against human SKMES1 cells after 3 days by MTT assay2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Antiproliferative activity of arborescidine alkaloids and derivatives.
AID432104Cytotoxicity against human J82 cells after 3 days by MTT assay2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Antiproliferative activity of arborescidine alkaloids and derivatives.
AID432103Cytotoxicity against human AGS cells after 3 days by MTT assay2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Antiproliferative activity of arborescidine alkaloids and derivatives.
AID432102Cytotoxicity against human MRC5 cells after 3 days by MTT assay2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Antiproliferative activity of arborescidine alkaloids and derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sb 206553
SB 206553: a high-affinity 5-HT(2C/2B) antagonist; structure given in first source		1.9910pyrroloindole
yohimbine
Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.. yohimbine : An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.		1.9910methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
hydrazine
diamine : Any polyamine that contains two amino groups.		2.110azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
etoposide
[no description available]		2.0510beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
tryptoline
tryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structure		1.9910beta-carbolines
yohimbane
yohimbane: from Gelsemium elegans; structure in first source		1.9910indole alkaloid fundamental parent;
indole alkaloid;
yohimban alkaloid
sb 200646
N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea: structure given in first source; a selective 5-HT(1C) receptor antagonist; SB-200646 is the HCl salt		1.9910indoles
n-(1-methyl-5-indolyl)-n'-(3-methyl-5-isothiazolyl)urea
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a 5-HT(2B) receptor antagonist; structure given in first source. 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea : A member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor.		1.99101,2-thiazoles;
indoles;
ureas		receptor modulator;
serotonergic antagonist
deplancheine
deplancheine: from Alstonia deplanchei; structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9910