Page last updated: 2024-11-12

dehydrothyrsiferol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dehydrothyrsiferol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11721258
CHEMBL ID23600
MeSH IDM0294309

Synonyms (3)

Synonym
dehydrothyrsiferol
CHEMBL23600
(1s)-4-[(2r,4as,6r,8ar)-2-[(2s,5r)-5-bromo-2,6,6-trimethyloxan-2-yl]-4a-methyl-3,4,6,7,8,8a-hexahydro-2h-pyrano[3,2-b]pyran-6-yl]-1-[(2r,5r)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]pent-4-en-1-ol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID164660Inhibition of protein phosphatase (PP2A) at 10 uM using fluorescein diphosphate2003Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.
AID609078Cytotoxicity against human Jurkat cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
AID164666Inhibitory activity against protein phosphatase (PP2A) at a concentration of 250 uM using fluorescein diphosphate as substrate2003Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.
AID609085Solubility of the compound in water2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
AID609080Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
AID164664Inhibitory activity against protein phosphatase (PP2A) at 1 uM using fluorescein diphosphate2003Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.
AID609084Inhibition of PPA2 using p-nitrophenyl phosphate as substrate at <100 uM by UV/visible absorption spectroscopic analysis2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
AID609083Cell cycle arrest in human Jurkat cells assessed as increase in apoptotic cells at sub-G1 phase at 20 uM after 72 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
AID681301TP_TRANSPORTER: inhibition of CFDA efflux (CFDA: 1 uM, DHT: 5-50 uM) in HL60/Adr cells2002International journal of molecular medicine, Nov, Volume: 10, Issue:5
Dehydrothyrsiferol does not modulate multidrug resistance-associated protein 1 resistance: a functional screening system for MRP1 substrates.
AID609079Cytotoxicity against human MM144 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
AID609082Induction of apoptosis in human Jurkat cells assessed as DNA breakdown in sub-G1 phase at 20 uM after 24 to 72 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
AID164658Inhibitory activity against protein phosphatase (PP2A) at a concentration of 100 uM using fluorescein diphosphate as substrate2003Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.
AID609081Cytotoxicity against human CADO-ES1 cells assessed as inhibition of cell proliferation after 72 hrs by XTT assay2011European journal of medicinal chemistry, Aug, Volume: 46, Issue:8
Cytotoxic oxasqualenoids from the red alga Laurencia viridis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.57 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]